Results 81 to 90 of about 13,235,717 (359)
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
La etica en la investigación: el caso con los tule (kunas) de Urabá, Colombia.
Biomédica: revista del Instituto Nacional de Salud, 2006 La investigación Cultura, alimentación y malaria entre los tule (kuna) se realizó en el resguardo de Caimán Nuevo, Urabá antioqueño, Colombia, y buscó analizar la prevalencia de la malaria y sus relaciones con la hipovitaminosis A y el estado nutricional,
Gloria Alcaraz, Adriana Correa
doaj +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Empresários e intelectuais: agentes culturais e valorização de um grupo étnico
Ciências Sociais Unisinos, 2014 The article aims to investigate an identity process of promotion of an ethnic group by focusing in the 1970s and 1980s, since this period is characterized by a process of mod- ernization of the economy in the region of Caxias Sul, in Rio Grande do Sul ...
Maria Clara Mocellin
doaj
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Journal of Ethnobiology and Ethnomedicine, 2011 BackgroundActivities and diet during the postpartum period are culturally dictated in many Southeast Asian cultures, and a period of confinement is observed.
V. Lamxay, H. D. de Boer, L. Björk
semanticscholar +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
Współczesne zabory – narody bezpaństwowe podzielone granicami [PDF]
Przegląd GeopolitycznyThe study contains the results of a geopolitical cartographic and linguistic analysis of the situation of stateless nations and ethnic groups. The aim of the analysis was to create a complete list of nations whose countries are divided by a modern ...
Piotr L. Wilczyński
doaj