Results 121 to 130 of about 6,446,544 (290)
Ethnic Studies Newsletter Vol. 5 No. 1
, 1984 Six page newsletter from the Ethnic Studies department dated Fall 1984. Newsletter is Volume 5, Number 1. Newsletter includes Feature on Dr. Joyce E. King; news items on Progress on S.C.
Ethnic Studies Department;
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Ethnic Studies Newsletter Summer 1992
, 1992 Sixteen page newsletter from the Ethnic Studies department dated Summer 1992. Newsletter includes articles titled Rodney King Beating: The Racist Verdict; 500 Years of Raza Resistance; Outrage at Racist Verdict; and A Word About the International Indian
Ethnic Studies Department;
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Ethnic Studies Newsletter Vol. 2 No. 4
, 1982 Four page newsletter from the Ethnic Studies department dated April 1982. Newsletter is Volume 2, Number 4. Newsletter features profile of Dr. Carolyn Naylor; Tenth Annual Conference on Minority and Ethnic Studies; Rev.
Ethnic Studies Department;
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
CULTURAL CHANGES IN INTERCULTURAL EDUCATION: THE CASE OF STUDENTS IN ETHNIC TRIQUI UAIM
Ra Ximhai, 2015 Globalization processes have overflowed their colonial influence in all societies that are now separate share ways of living and coexist without the need for physical contact between individuals themselves within it.
Francisco A. Romero-Leyva +2 more
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