MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
African Mozambican immigrants : narrative of immigration and identity, and acculturation strategies in Portugal and England [PDF]
This research project aims to argue that the notions of ethnic identity, ethnic group and ethnicity should be thought of as socially constructed. In order to strengthen the above assumption, fieldwork was undertaken by examining African Mozambicans ...
Khan, Sheila
core
How Class Influences the Ethnic Identity of Chinese Immigrants in the UK: Citizenship, Work, and Solidarity. [PDF]
Br J SociolYin Z.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Ethnic identity can moderate the relationship between self-esteem, peer relationships, and mental well-being of adolescent and youth. [PDF]
BMC PsycholMussina ZA, Lawrence KC.
europepmc +1 more source
Conceptualizing the Role of Racial-Ethnic Identity in U.S. Adolescent Social Technology Use and Well-Being. [PDF]
Transl Issues Psychol Sci, 2023 Hernandez JM +2 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 2006 This book chapter is based on a paper presented at the European Maya Conference, Bonn University, 2004. It strives at reconstructing Yucatec Maya identity from the Books of Chilam Balam and certain texts are highlighted that uses terms connected to ...
Liljefors Persson, Bodil
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source