Results 41 to 50 of about 136,141 (296)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Evaluating the psychometric properties of the multigroup ethnic identity measure (MEIM) within the United Kingdom

open access: yes, 2010
In the present study, we examined the psychometric properties of the Multigroup Ethnic Identity Measure (MEIM) (Phinney, 1992; Phinney & Alipuria, 1990) among an ethnically diverse sample within the United Kingdom.
Wright, B   +3 more
core   +1 more source

Discrimination and academic (dis)engagement of ethnic-racial minority students: a social identity threat perspective [PDF]

open access: yes, 2019
In this paper we discuss the social identity processes by which discrimination can have an impact on ethnic-racial minority group students’ academic engagement.
Verkuyten, Maykel   +4 more
core   +1 more source

Varieties of Ethnic Self-Identities: Children of Immigrants in Middle Adulthood

open access: yesRSF: The Russell Sage Foundation Journal of the Social Sciences, 2018
This mixed-methods longitudinal study examines ethnic self-identity change from mid-adolescence to middle adulthood among a representative sample of adult children of immigrants first surveyed in 1992 in San Diego.
Cynthia Feliciano, Rubén G. Rumbaut
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Ethnic In-Group Favoritism Among Minority and Majority Groups: Testing the Self-Esteem Hypothesis Among Preadolescents [PDF]

open access: yes, 2007
The self-esteem hypothesis in intergroup relations, as proposed by social identity theory (SIT), states that successful intergroup discrimination enhances momentary collective self-esteem.
Verkuyten, Maykel   +2 more
core   +1 more source

Measuring Ethnic Identity and Its Impact on Economic Behavior [PDF]

open access: yes
The paper advocates for a new measure of the ethnic identity of migrants, models its determinants and explores its explanatory power for various types of their economic performance. The ethnosizer, a measure of the intensity of a person's ethnic identity,
Amelie Constant, Klaus F. Zimmermann
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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