Results 71 to 80 of about 958,939 (310)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Features of Ethno-Linguistic Identity Characteristic for Representatives of Different Ukrainian Linguistic Groups

open access: yesПсихолінгвістика, 2019
The article analyzes features of ethno-linguistic identity characteristic for representatives of the main Ukrainian language groups: Ukrainian-speaking Ukrainians, Russian-speaking Ukrainians and Russian-speaking Russians.
Eliso Hryshchuk, Alla Kovalenko
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

open access: yesFEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Management of Health System for Ethnic Minorities [PDF]

open access: yes
The concept of ethnic minority refers to a different ethnic group, living in a residential country, with a different birth place and ethnic membership, different language, religion and citizenship, and different culture.
Cristina Teodora NEAGU
core  

Diversity in the Heartland of America: The Impact on Human Development in Indiana [PDF]

open access: yes, 2018
This article is the third in a series of studies measuring the impact of cultural diversity on human development. We disaggregate cultural diversity into three components: ethnicity, language, and religion.
Boothby, Lisa   +3 more
core   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

An Observational Framework to the Zipfian Analysis among Different Languages: Studies to Indonesian Ethnic Biblical Texts [PDF]

open access: yes, 2007
The paper introduces the used of Zipfian statistics to observe the human languages by using the same (meaning) corpus/corpora but different in grammatical and structural utterances.
Situngkir, Hokky
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Mother Tongue in the Context of a Polyethnic Country

open access: yesOriental Studies, 2018
The article analyzes the role of mother tongue in present-day polyethnic countries, specificity of ethnic language identity, correlation between the level of ethno-linguistic identity and language competence through the example of the Oirat-Kalmyks. In
A. N. Bitkeeva
doaj   +1 more source

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