Results 181 to 190 of about 171,695 (305)

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović   +11 more
wiley   +1 more source

EDTA-Dependent Pseudothrombocytopenia

open access: yesTurkish Journal of Hematology, 2012
Aysenur Bahadır   +3 more
doaj   +1 more source

The Effect of Electrolyte pH and Impurities on the Stability of Electrolytic Bicarbonate Conversion

open access: yesChemSusChem, Volume 18, Issue 6, March 15, 2025.
The performance of bicarbonate electrolysis is largely controlled by the electrolyte inlet pH, the distance between the membrane and electrode, and the impurities present in the electrolyte. By complexing trace metal ions with ethylenediaminetetraacetic acid (EDTA), stability can significantly be improved and longer term operation can be achieved ...
Iris Burgers   +3 more
wiley   +1 more source

Whole tissue imaging of cellular boundaries at sub‐micron resolutions for deep learning cell segmentation: Applications in the analysis of epithelial bending of ectoderm

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background To understand cellular morphology, biologists have relied on traditional optical microscopy of tissues combined with tissue clearing protocols to image structures deep within tissues. Unfortunately, these protocols often struggle to retain cell boundary markers, especially at high enough resolutions necessary for precise cell ...
Sam C. P. Norris   +2 more
wiley   +1 more source

The segregation of Calb1, Calb2, and Prph neurons reveals distinct and mixed neuronal populations and projections to hair cells in the inner ear and central nuclei

open access: yesDevelopmental Dynamics, EarlyView.
Three populations of hair cells have a distinct expression of Calb1 and Calb2. (A, A′D) The central is highly positive for Calb1 while surrounding HC are positive for Calb2. Later, a calyx forms primarily with Calb1. (B, B′, D′, D″) Saccule and utricle start out positive for Calb2 but will upregulate the Calb1 in the striola that is primarily forming ...
Jeong Han Lee   +6 more
wiley   +1 more source

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