Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice
Advanced Healthcare Materials, EarlyView.A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec +5 more
wiley +1 more source
Time after time: the chronology of photosynthesis inhibition by ethylene. [PDF]
Plant PhysiolDubois M.
europepmc +1 more source
3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence
Advanced Healthcare Materials, EarlyView.Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes +11 more
wiley +1 more source
Phytoglobin Scavenging of Nitric Oxide Is Associated With Ethylene Reduction and Drought Tolerance in Oat (Avena sativa). [PDF]
Physiol PlantMontilla-Bascon G +3 more
europepmc +1 more source
Advanced Materials, Volume 37, Issue 13, April 2, 2025.Leveraging the numerous advantages of ammonium‐ion (NH₄⁺)—including cost‐effectiveness, low corrosiveness, preferential orientation, and rapid diffusion kinetics—aqueous NH₄⁺ batteries (AAIBs) have gained significant attention. This review highlights and evaluates the progress of AAIBs utilizing organic electrode materials such as small molecules ...
Mangmang Shi, Xiaoyan Zhang
wiley +1 more source
Identification and Functional Exploration of the <i>ALKBH</i> Gene Family in Oriental Melon Fruit Ripening. [PDF]
Int J Mol SciZhang C, Guo X, Zhang Y, Pang H, Chen Q.
europepmc +1 more source
Thermal Processing Creates Water‐Stable PEDOT:PSS Films for Bioelectronics
Advanced Materials, Volume 37, Issue 13, April 2, 2025.Instead of using chemical cross–linkers, it is shown that PEDOT:PSS thin films for bioelectronics become water‐stable after a simple heat treatment. The heat treatment is compatible with a range of rigid and elastomeric substrates and films are stable in vivo for >20 days.
Siddharth Doshi +16 more
wiley +1 more source
The Importance of Branch Placement on the Dilute Solution Properties of Comb-like Macromolecules. [PDF]
MacromoleculesIvancic RJS +6 more
europepmc +1 more source
Advanced Materials, Volume 37, Issue 13, April 2, 2025.Metal‐covalent organic frameworks (MCOFs) are novel porous materials that exhibit the advantages of covalent and metal‐organic frameworks. However, it is extremely difficult to resolve their atomic structure and better understand their structure‐properties relation. This work utilizes a synergistic combination of advanced microscopy, spectroscopic, and
Seán Hennessey +11 more
wiley +1 more source
Ambident reactivity of enolizable 5-mercapto-1<i>H</i>-tetrazoles in trapping reactions with in situ-generated thiocarbonyl <i>S</i>-methanides derived from sterically crowded cycloaliphatic thioketones. [PDF]
Beilstein J Org ChemMlostoń G +5 more
europepmc +1 more source