Results 91 to 100 of about 32,807 (224)

Elexacaftor-tezacaftor-ivacaftor in people with cystic fibrosis harbouring two CFTR Class I variants: real-world data from the French compassionate programmeResearch in context

EClinicalMedicine
Summary: Background: The European Medicines Agency has recently expanded the label of elexacaftor-tezacaftor-ivacaftor (ETI) to all people with cystic fibrosis (pwCF) aged 2 years and older who have at least one non-Class I mutation in the cystic ...
Pierre-Régis Burgel, Emmanuelle Girodon, Neeraj Sharma, Caroline Raynal, Jennifer Da Silva, Souphatta Sasorith, Clémence Martin, Isabelle Sermet-Gaudelus, Karen Raraigh   +8 more
doaj   +1 more source

On Our Cosmic (In)significance

Ratio, EarlyView.
ABSTRACT This article discusses three interpretations of cosmic significance, all of which reveal something important about the notion of significance. Along the way, it proposes a unified view of significance by combining elements of each of the views.
Oskari Sivula
wiley   +1 more source

Pregnancy-related effect on elexacaftor, tezacaftor and ivacaftor pharmacokinetics in women with cystic fibrosis. [PDF]

Br J Clin Pharmacol
Aim The number of pregnancies among women with cystic fibrosis (wwCF) has steadily increased over the past decade. However, the pharmacokinetics (PK) of elexacaftor–tezacaftor–ivacaftor (ETI) during gestation remains uncharacterized, despite its widespread use in this population.
Magnas P, Bouazza N, Foissac F, Urien S, Froelicher-Bournaud L, Lui G, Guillemart V, Carlier N, Da Silva J, Fesenbeckh J, Kanaan R, Honoré I, Martin C, Treluyer JM, Tsatsaris V, Burgel PR, Benaboud S.   +16 more
europepmc   +2 more sources

Due Diligence Regulation and Sustainability Governance in Value Chains: Lessons From the South African Wine Sector

Regulation &Governance, EarlyView.
ABSTRACT A recent raft of due diligence regulation (DDR) addressing social and environmental conditions in global value chains (GVCs) has spread across the UK and Europe. An emerging literature on DDR highlights the politics of its formation. Yet, we know little about how existing sustainability governance along GVCs interacts with DDR or the wider ...
Matthew Alford, Reena das Nair, Margareet Visser, Stefano Ponte, Shingie Chisoro   +4 more
wiley   +1 more source

Longitudinal changes in habitual physical activity in adult people with cystic fibrosis in the presence or absence of treatment with elexacaftor/tezacaftor/ivacaftor

Frontiers in Sports and Active Living
BackgroundHabitual physical activity (PA) and exercise training are accepted as important aspects of care for people with cystic fibrosis (pwCF) to improve health-related measures of physical fitness, which in turn have a positive impact on quality of ...
Wolfgang Gruber, Wolfgang Gruber, Florian Stehling, Christopher Blosch, Stefanie Dillenhoefer, Margarete Olivier, Folke Brinkmann, Cordula Koerner-Rettberg, Cordula Koerner-Rettberg, Sivagurunathan Sutharsan, Uwe Mellies, Christian Taube, Matthias Welsner   +12 more
doaj   +1 more source

Grounds for Accountability: Preparedness for Supply Chain Due Diligence Legislation in Canada

Regulation &Governance, EarlyView.
ABSTRACT Canada is under growing pressure to adopt mandatory supply chain due diligence legislation to hold corporations accountable for environmental and social harms embedded in global supply chains. In response, the Government of Canada is exploring policy options for stricter supply chain regulations, including legislative measures such as the ...
Emma L. Bowick, Rachel S. Friedman, Michaela L. Meil, Sophia L. Carodenuto   +3 more
wiley   +1 more source

Die deutsche Version des „Early Trauma Inventory” (ETI)

, 2011
Zusammenfassung. Für den deutschsprachigen Raum stehen derzeit kaum evaluierte Instrumente zur Erfassung traumatischer Ereignisse in der Kindheit und Jugend zur Verfügung.
Driessen, Martin ; https://orcid.org/, Christoph Mensebach, Nicole Schlosser, Camille Schaffrath, Mensebach, Christoph, Nina Rullkoetter, Beblo, Thomas, Christine Heim, Martin Driessen, Spitzer, Carsten, Katja Wingenfeld, Schaffrath, Camille, Rullkoetter, Nina, Wingenfeld, Katja, Carsten Spitzer, Schlosser, Nicole, Heim, Christine, Thomas Beblo   +17 more
core   +1 more source

Contestation and Compromise in Shaping the European Union's Corporate Sustainability due Diligence Directive: Implications for Global Value Chain Governance

Regulation &Governance, EarlyView.
ABSTRACT This paper explores the European Union's Corporate Sustainability Due Diligence Directive (CS3D) in the context of ongoing debates on private and public governance of global value chains (GVCs). Conceptually, it draws on neo‐Gramscian perspectives to analyze how contestation and compromise between distinct stakeholders and dynamics of hegemony
Louise Curran, Matthew Alford, Khalid Nadvi   +2 more
wiley   +1 more source

Diş Eti Hastalığı Kalp Kapağını Kireçlendiriyor mu?

Yeni araştırma, diş eti hastalığına neden olan bakterilerin kalp kapağında kireçlenmeye yol açabileceğini ortaya koydu. Diş eti hastalığı, kalp kapağı kireçlenmesi, aort kapak darlığı ve ağız sağlığı arasındaki ilişki tüm detaylarıyla bu haberde.

core   +1 more source

Re‐Imagining Regulatory Governance

Regulation &Governance, EarlyView.
ABSTRACT This paper invites the readers to rethink regulatory governance by examining how trust‐based and rule‐based governance interact. To do this, it uses analytical narratives of three fictional polities: “Trustland”, “Regland”, and “Concordia”. Each polity represents a stylized model of governance: Trustland is anchored in trust‐based governance ...
David Levi‐Faur
wiley   +1 more source