Results 221 to 230 of about 1,913,301 (392)

Dysfunctional Decidual CD4+T Cells Induce Recurrent Pregnancy Loss via Palmitoylation‐Dependent Tim‐3 Lysosomal Sorting and Degradation

open access: yesAdvanced Science, EarlyView.
Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui   +6 more
wiley   +1 more source

Primary Leiomyosarcoma of Ovary [PDF]

open access: yes, 2009
Primary ovarian leiomyosarcomas is a rare neoplasm which comprises less than 3% of ovarian tumors. Their origin, etiology, histologic features, clinical behavior, and optimal treatment are still obscure.
Kaul, R, Sharma, J
core  

Mendelian randomization reveals potential causal relationships between cellular senescence-related genes and multiple cancer risks

open access: yesCommunications Biology
Cellular senescence is widely acknowledged as having strong associations with cancer. However, the intricate relationships between cellular senescence-related (CSR) genes and cancer risk remain poorly explored, with insights on causality remaining ...
Xunan Qiu   +5 more
doaj   +1 more source

Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.

open access: yesJournal of the American Medical Directors Association, 2011
R. Fielding   +24 more
semanticscholar   +1 more source

A MXene‐Based Nanothermal Knife Inhibits Aggresome‐Mediated Persister Formation for Preventing Dental Caries

open access: yesAdvanced Science, EarlyView.
Early childhood caries (ECC) involves cariogenic persisters that evade antimicrobial treatment. Persisters achieve this by downregulating heat shock proteins (HSPs) and formation of protein aggregates. Ti3C2 MXene‐based photothermal therapy (PTT) acts as a “nanothermal knife,” disrupting membranes, upregulating HSPs, inhibits aggregates, prevents ...
Yinyin Zhang   +8 more
wiley   +1 more source

THE ETIOLOGY OF RHEUMATIC FEVER

open access: bronze, 1949
Byron H. Waksman
openalex   +1 more source

ETIOLOGY OF YELLOW FEVER [PDF]

open access: bronze, 1921
Alfred E. Cohn, Hideyo Noguchi
openalex   +1 more source

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

open access: yesAdvanced Science, EarlyView.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen   +14 more
wiley   +1 more source

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