Results 21 to 30 of about 1,338,278 (211)

Expression characteristics and their functional role of IGFBP gene family in pan-cancer

BMC Cancer, 2023
Background Insulin-like growth factor binding proteins (IGFBPs) are critical regulators of the biological activities of insulin-like growth factors. The IGFBP family plays diverse roles in different types of cancer, which we still lack comprehensive and ...
Yingnan Liu, Shixuan Shen, Ziwei Yan, Lirong Yan, Hanxi Ding, Ang Wang, Qian Xu, Liping Sun, Yuan Yuan   +8 more
doaj   +1 more source

The Involvement of TRIB3 and FABP1 and Their Potential Functions in the Dynamic Process of Gastric Cancer

Frontiers in Molecular Biosciences, 2021
Background: Dysregulated expression of TRIB3 and FABP1 have been previously observed in human cancer tissues. However, there are little information as to their expression change in dynamic gastric diseases and the functional roles.Methods: Tissues from a
Songyi Liu, Songyi Liu, Songyi Liu, Chuxuan Ni, Chuxuan Ni, Chuxuan Ni, Yizhi Li, Yizhi Li, Yizhi Li, Honghao Yin, Honghao Yin, Honghao Yin, Chengzhong Xing, Chengzhong Xing, Chengzhong Xing, Yuan Yuan, Yuan Yuan, Yuan Yuan, Yuehua Gong, Yuehua Gong, Yuehua Gong   +20 more
doaj   +1 more source

A newly identified heterozygous lipoprotein lipase gene mutation (Cys239–>stop/TGC972–>TGA; LPLobama) in a patient with primary type IV hyperlipoproteinemia.

Journal of Lipid Research, 1994
We investigated measures for identification of heterozygous lipoprotein lipase (LPL) deficiency in unrelated subjects with primary type IV hyperlipoproteinemia in order to acquire a helpful clue for understanding the correlation between ...
A Takagi, Y Ikeda, A Mori, Z Tsutsumi, K Oida, T Nakai, A Yamamoto   +6 more
doaj   +1 more source

Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer

Journal of Translational Medicine, 2023
Mitochondria determine the physiological status of most eukaryotes. Mitochondrial dynamics plays an important role in maintaining mitochondrial homeostasis, and the disorder in mitochondrial dynamics could affect cellular energy metabolism leading to ...
Ao-ran Liu, Zhi Lv, Zi-wei Yan, Xiao-yang Wu, Li-rong Yan, Li-ping Sun, Yuan Yuan, Qian Xu   +7 more
doaj   +1 more source

A Dynamic Transcriptome Map of Different Tissue Microenvironment Cells Identified During Gastric Cancer Development Using Single-Cell RNA Sequencing

Frontiers in Immunology, 2021
Gastric cancer (GC) development trends have identified multiple processes ranging from inflammation to carcinogenesis, however, key pathogenic mechanisms remain unclear.
Honghao Yin, Honghao Yin, Honghao Yin, Rui Guo, Rui Guo, Rui Guo, Huanyu Zhang, Huanyu Zhang, Huanyu Zhang, Songyi Liu, Songyi Liu, Songyi Liu, Yuehua Gong, Yuehua Gong, Yuehua Gong, Yuan Yuan, Yuan Yuan, Yuan Yuan   +17 more
doaj   +1 more source

Pepsinogen C expression, regulation and its relationship with cancer

Cancer Cell International, 2017
Pepsinogen C (PGC) belongs to the aspartic protease family and is secreted by gastric chief cells. PGC could be activated to pepsin C and digests polypeptides and amino acids, but as a zymogen PGC’s functions is unclear.
Shixuan Shen, Jingyi Jiang, Yuan Yuan
doaj   +1 more source

Aberrantly methylated-differentially expressed genes and pathways in colorectal cancer

Cancer Cell International, 2017
Background Methylation plays an important role in the etiology and pathogenesis of colorectal cancer (CRC). This study aimed to identify aberrantly methylated-differentially expressed genes (DEGs) and pathways in CRC by comprehensive bioinformatics ...
Jingwei Liu, Hao Li, Liping Sun, Zhenning Wang, Chengzhong Xing, Yuan Yuan   +5 more
doaj   +1 more source

MiR-1539 and Its Potential Role as a Novel Biomarker for Colorectal Cancer

Frontiers in Oncology, 2021
PurposeWe investigated microRNA (miR) 1539 as a potential biomarker for predicting the risk and pathobiological behavior of colorectal cancer (CRC).MethodsOur strategy consisted of analyzing 100 serum samples from 51 CRC patients, 49 healthy controls ...
Xueyang Cui, Xueyang Cui, Xueyang Cui, Zhi Lv, Zhi Lv, Zhi Lv, Hanxi Ding, Hanxi Ding, Hanxi Ding, Chengzhong Xing, Chengzhong Xing, Chengzhong Xing, Yuan Yuan, Yuan Yuan, Yuan Yuan   +14 more
doaj   +1 more source

An Integrated Pan-Cancer Analysis of 33 Human Cancers Reveals the Potential Clinical Implications and Immunotherapeutic Value of C-X-C Motif Chemokine Ligand 13

Frontiers in Oncology, 2022
BackgroundC-X-C Motif Chemokine Ligand 13 (CXCL13) plays a crucial part in the pathogenesis of numerous lymphoproliferative disorders, inflammatory responses, and autoimmune diseases.
Huanyu Zhang, Huanyu Zhang, Huanyu Zhang, Honghao Yin, Honghao Yin, Honghao Yin, Jing Chen, Jing Chen, Jing Chen, Yuan Yuan, Yuan Yuan, Yuan Yuan   +11 more
doaj   +1 more source

Key elements involved in Epstein–Barr virus-associated gastric cancer and their network regulation

Cancer Cell International, 2018
Background The molecular mechanism of Epstein–Barr virus (EBV)-associated gastric cancer (EBVaGC) remains elusive. A collection of molecular regulators including transcription factor and noncoding RNA (ncRNAs) may affect the carcinogenesis of EBVaGC by ...
Jing-jing Jing, Ze-yang Wang, Hao Li, Li-ping Sun, Yuan Yuan   +4 more
doaj   +1 more source