Results 71 to 80 of about 124,631 (174)

Crystal Structures, Molecular Docking and In Vitro Investigations of Two 4-Substituted 2-(5,5-dimethyl-3-styrylcyclohex-2-enylidene)malononitrile Derivatives as Potential Topoisomerase II Inhibitors

Crystals
Type II topoisomerases (TOP2s) play a key role in altering the DNA topology by transiently cleaving both strands of a DNA duplex. Therefore, increased TOP2 activity is associated with many cancers.
Martina I. Peeva, Maya G. Georgieva, Aneliya A. Balacheva, Maria Ponticelli, Ivan P. Bogdanov, Tsonko Kolev, Luigi Milella, Hans-Georg Stammler, Nikolay T. Tzvetkov   +8 more
doaj   +1 more source

Comparison of Anticancer Activity and HPLC-DAD Determination of Selected Isoquinoline Alkaloids from Thalictrum foetidum, Berberis sp. and Chelidonium majus Extracts

Molecules, 2019
Background: Plants are an important origin of natural substances that the raw material for various pharmaceutical and therapeutic applications due to the presence of phytochemicals, such as alkaloids. Alkaloids, which are found in different plant species,
Anna Petruczynik, Tomasz Tuzimski, Tomasz Plech, Justyna Misiurek, Karolina Szalast, Grażyna Szymczak   +5 more
doaj   +1 more source

Treatment of Adult Patients with Relapsed/Refractory B-Cell Philadelphia-Negative Acute Lymphoblastic Leukemia [PDF]

, 2019
The majority of adult patients affected by B-cell acute lymphoblastic leukemia (B-ALL) will relapse after an initial response, while approximately 20% will display primary resistant disease. Patients suffering from relapsed/refractory B-ALL have a very
Lanza, Francesco, Maffini, Enrico, Saraceni, Francesco   +2 more
core   +1 more source

Occupational rhinosinusitis due to etoposide, an antineoplastic agent

Scandinavian Journal of Work, Environment & Health, 2010
OBJECTIVE: This paper reports a rare case of an occupational hypersensitivity reaction to an antineoplastic agent. METHODS: This is a clinical case report of a 45-year-old nurse who developed throat irritation and chronic nasal congestion followed by ...
Harald W Meyer, Per Stahl Skov
doaj   +1 more source

Hypersensitivity reaction to etoposide. A case report [PDF]

Farmacia Hospitalaria, 2014
M. Mullera Martí, M. Riba Solé, E. Fernández de Gamarra Martínez, M.ª A. Mangues Bafalluy   +3 more
doaj   +1 more source

Construction and mechanism of a small cell lung cancer cell line resistant to EP chemotherapy scheme

陆军军医大学学报
Objective To construct the etoposide (VP-16) combined with cisplatin (DDP) chemotherapy scheme (EP chemotherapy scheme) resistant small cell lung cancer (SCLC) cell line H446/EP and to identify the drug resistance characteristics and explore the ...
LIU Mingpu, LIU Mingpu, WANG Hongmei, WANG Hongmei   +3 more
doaj   +1 more source

TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup. [PDF]

, 2017
Purpose: Current clinical parameters do not stratify indolent from aggressive prostate cancer. Aggressive prostate cancer, defined by the progression from localized disease to metastasis, is responsible for the majority of prostate cancer–associated ...
Alshalalfa, Mohammed,, Bowden, Michaela,, Brown, Myles,, Davicioni, Elai,, Den, Robert B.,, Ellis, Leigh,, Eng, Kevin H.,, Erho, Nicholas,, Feng, Felix Y.,, Galbo, Phillip,, Goodrich, David W.,, Gray, Kathryn P.,, Huang, Ying,, Jenkins, Robert B.,, Karnes, R. Jeffrey,, Ku, Sheng Yu,, Labbé, David P.,, Lund University., Rosario, Spencer,, Ross, Ashley E., Schaeffer, Edward M.,, Sjöström, Martin,, Spratt, Daniel E.,, Sweeney, Christopher J.,, Wadosky, Kristine M.,   +24 more
core   +2 more sources

A novel mutation panel for predicting etoposide resistance in small-cell lung cancer

Drug Design, Development and Therapy, 2019
Zhengang Qiu,1,2,* Anqi Lin,1,* Kun Li,1,* Weiyin Lin,1,* Qiongyao Wang,1 Ting Wei,1 Weiliang Zhu,1 Peng Luo,1 Jian Zhang11Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, People’s Republic of China ...
Qiu Z, Lin A, Li K, Lin W, Wang Q, Wei T, Zhu W, Luo P, Zhang J   +8 more
doaj  

Proteomic profile of KSR1-regulated signalling in response to genotoxic agents in breast cancer [PDF]

, 2015
Kinase suppressor of Ras 1 (KSR1) has been implicated in tumorigenesis in multiple cancers, including skin, pancreatic and lung carcinomas. However, our recent study revealed a role of KSR1 as a tumour suppressor in breast cancer, the expression of which
A Franceschini, AA Adjei, Arnhild Grothey, B Gyorffy, Cancer Genome Atlas Network, F Yan, F Yan, Georgios Giamas, H Xing, H Zhang, H Zhang, H Zhang, HR Xing, Hua Zhang, I Youlyouz-Marfak, J Cox, J Cox, J Lozano, J Stebbing, J Wielemaker, J Xu, J Zhang, Joao Nunes, Justin Stebbing, JV Olsen, K Kornfeld, L Hannesdottir, M Alcoceba, M Ashburner, M Kim, M Sundaram, M Therrien, M Therrien, Nicos Angelopoulos, NR Michaud, O Tacar, P Tymoszuk, PJ Klutho, R Kaneno, S Datta, S Falcon, S Zhu, Y Cao, Y Pommier, Y Xu, Y Zhang, Y Zhang, Yichen Xu, YJ Jeon   +48 more
core   +3 more sources

Intravenous versus oral etoposide : efficacy and correlation to clinical outcome in patients with high-grade metastatic gastroenteropancreatic neuroendocrine neoplasms (WHO G3) [PDF]

, 2018
High-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs, G3) are aggressive cancers of the digestive system with poor prognosis and survival.
Ali, Abir Salwa, Gronbaek, Henning, Grönberg, Malin, Hjortland, Geir Olav, Janson, Eva Tiensuu, Knigge, Ulrich, Ladekarl, Morten, Langer, Seppo W., Sorbye, Halfdan, Vestermark, Lene Weber, Welin, Staffan, Österlund, Pia   +11 more
core   +5 more sources