Results 201 to 210 of about 9,594,514 (288)

Comparative Analysis of Bioreactor Design and Scale‐Up for Cultivated Meat Using Monte Carlo‐Based Timescale Modeling

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cultivated meat offers a sustainable alternative to conventional livestock production but faces significant scale‐up challenges, particularly in bioreactor design for mammalian cell suspension cultures. This study presents a comparative analysis of stirred tank reactors (STR), bubble columns (BC), and airlift reactors (ALR) to assess their ...
Pieter Jan Theodoor Brorens, Marcel Ottens, Cees Haringa   +2 more
wiley   +1 more source

Model‐Driven Monitoring and Parameter‐Based Development of an Escherichia coli Fed‐Batch Process for Production of a Fab Antibody Fragment Across Scales

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Maintaining consistent cellular physiology during bioprocess scale‐up or scale‐down is key to developing robust processes. However, the reliability of scale‐down bioreactor systems remains debated. Although the calibration of physiological parameters in mechanistic models across scales has been proposed as a scale‐down strategy, few studies ...
Fabian Schröder‐Kleeberg, Lucas Kaspersetz, Markus Zoellkau, Markus Glaser, Markus Brunner, Christian Bosch, Annina Kemmer, M. Nicolas Cruz Bournazou, Peter Neubauer   +8 more
wiley   +1 more source

Building a single market for data: Data spaces as pro-competitive infrastructure. [PDF]

Data Brief
Konstantopoulou ES.
europepmc   +1 more source

Reducing Cooling Costs for Sustainable Food Biomanufacturing With Thermotolerant Cupriavidus necator H16 Mutant

Biotechnology and Bioengineering, EarlyView.
With a thermotolerant C. necator mutant the SCP production costs can be decreased by $0.98/kg. ABSTRACT Autotrophic CO2 conversion to Single Cell Protein (SCP) using H2 and O2 is gaining commercial traction for food and feed production. Cupriavidus necator H16 is a key chassis organism for this “knallgas” fermentation, but industrial operation is ...
Lars Puiman, James Kemp Heffernan, Esteban Marcellin   +2 more
wiley   +1 more source

Two-faced Janus? Consent to participate in research and consent to data processing in the EHDS era: a comparative analysis of requirements and standards in eight European countries. [PDF]

J Law Biosci
Marelli L, Colussi I, Schlünder I, Bahr A, Huys I, Krekora-Zając D, Kuráň J, Lalova-Spinks T, Mascalzoni D, Matei M, Nicolás P, Southerington T.   +11 more
europepmc   +1 more source

Optimized micro‐sized cell sphere‐matrix niche co‐aggregates promote efficient oral and craniomaxillofacial bone regeneration

BMEMat, EarlyView.
The construct of cell‐niche co‐aggregates (GelMA‐SHED sphere‐DDMPs) promotes cranial and periodontal bone regeneration and ensures angiogenic‐osteogenic coupling by downregulating miR‐34c‐5p to enhance the expression of NOTCH1 and its intracellular domain (NICD).
Xiao‐Hui Zhang, Shi‐Han Mu, Yi‐Han Xiao, Lu‐Fan Yang, Peng‐Fei Wang, Teng‐Fei Hu, Jun‐Xi He, Jiong‐Zhen Piao, Sha Zhang, Jin‐Yu Liu, Yi‐De He, Ying‐Ying Wu, Si‐Qi Ying, Xin‐Yue Cai, Chen‐Han Li, Zi‐Qi Zhang, Xiao Lei, Ji Chen, Jian‐Fei Liang, Yan Jin, Bing‐Dong Sui, Chao Ma, Chen‐Xi Zheng, Fang Jin   +23 more
wiley   +1 more source

The EU AI Act: implications and compliance guidance for healthcare facilities. [PDF]

Front Digit Health
Dennstädt F, Hastings J, Windisch P, Jovanovic A, Marić TŽ, Brüningk S, Aebersold DM, Knopf A, Cihoric N.   +8 more
europepmc   +1 more source

Toward clone‐on‐a‐chip: Ethical and legal considerations for organ‐on‐a‐chip evolution

BMEMat, EarlyView.
The term “clone‐on‐a‐chip (CoC)” is introduced as a conceptual warning for personalized organ‐on‐a‐chip platforms and not to suggest technological feasibility, where a CoC ethical discussion extends beyond issues arising from the requirements for informed consent, property rights, commercialization efforts, and cell sourcing to include potentially ...
Muhammed Erkan Karabekmez, Aliakbar Ebrahimi, Hamed Ghorbanpoor, Nicole Bassous, Su Ryon Shin, Yu Shrike Zhang, Huseyin Avci   +6 more
wiley   +1 more source

Quantifying effects of the European Health Data Space on the app ecosystem and data access. [PDF]

NPJ Digit Med
Brückner S, Riedel R, Hetmank S, Fritsch K, Freyer O, Gilbert S.   +5 more
europepmc   +1 more source

Animal empathy reconsidered: a multidimensional profile account

Biological Reviews, EarlyView.
ABSTRACT Empathy is the glue that holds societies together and yet several fundamental questions about empathy persist. What is empathy (the definitional question)? Is it uniquely human and, if not, which nonhuman animals possess empathy (the distribution question)? Which type or quality of empathy is realized in different species (the quality question)
Albert Newen, Maja Griem, Ludwig Huber, Thomas Bugnyar, Aaron Blaisdell, Simone Pika   +5 more
wiley   +1 more source