Results 181 to 190 of about 125,560 (309)

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

SEIZING THE EU INTEGRATION IN A NEW GEOPOLITICAL ERA

Iustinianus Primus Law Review
The reshaped geopolitical context has reenergized the enthusiasm on the future round of EU enlargement. The new four-pillar Growth Plan for Western Balkans already sent a very powerful message that the enlargement is back on the agenda.
Aleksandar Stojkov, Fatmir Besimi
doaj  

Introns as Protective Buffers Against Transposable Elements Invasion During Genome Gigantism in a Newt. [PDF]

Genes Cells
Bou K, Agata K.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Fragile research systems, brain drain, and predatory publishing in under-resourced countries. [PDF]

Microlife
Jonjić S, Karahan ZC, Lopez-Garcia P, Williams P, Gerbin A, Traven L, Timmis KN, Rainey PB.   +7 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Redefining Idiopathic Normal Pressure Hydrocephalus Using AI-Driven Brain Volumetry. [PDF]

Biomedicines
Sahuquillo J, Al-Nusaif M, Sahuquillo-Muxi A, Duch P, Poca MA, On Behalf Of The Alzheimer's Disease Neuroimaging Initiative.   +5 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

EU Enlargement in a New Light

Intereconomics, 2022
doaj   +1 more source

From structured surveys to outbreak investigations: advancing genomic surveillance of carbapenem-resistant Enterobacterales within the European Antimicrobial Resistance Genes Surveillance Network. [PDF]

Front Public Health
Kohlenberg A, Linkevicius M, Alm E, Robesyn E, Svartström O, Palm D, Monnet DL, Plachouras D, Albiger B.   +8 more
europepmc   +1 more source