Results 51 to 60 of about 1,868 (228)

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

MOŞTENIREA ORDOLIBERALĂ ŞI VIITORUL GUVERNANŢEI ECONOMICE EUROPENE [PDF]

Revista de Știinţe Politice şi Relaţii Internaţionale
This article develops a critical reconstruction of Ordoliberalism for the European Union’s contemporary political economy. It challenges the widespread tendency to equate ordoliberal thought with the austerity-centred governance of the euro-area crisis ...
RĂDULESCU, BOGDAN-GEORGE
doaj  

Leveraging smart governancefor Ukraine's macroeconomic recovery and stabilisation

Smart Cities and Regional Development Journal
Objectives: The study aims to develop a strategic framework for integrating smart governance instruments into Ukraine's macroeconomic policy to enhance recovery and stabilisation.
Nataliia FEDIRKO
doaj   +1 more source

The Plant‐to‐Plant Circular Strategy: Coupling Photodegradation and Phytoremediation With Plant‐Based Nanomaterials for Plastic Degradation

Advanced Science, EarlyView.
Plant‐based nanomaterials derived from alfalfa serve as dual‐function catalysts, coupling photodegradation and phytoremediation to degrade polyethylene under UV‐A light and in soil. The nanomaterials work synergistically with alfalfa and soil microbes, achieving efficient plastic breakdown without trophic transfer.
Haoran Liu, Lena Ciric, Yuheng Wang, Ziru Pei, Manpreet Bhatti   +4 more
wiley   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source

Independent Fiscal Institutions: A Comparative Analysis

Transylvanian Review of Administrative Sciences, 2013
The sovereign debt crisis and the new legal framework of European economic governance have forced most of the EU Countries to adopt stricter fiscal rules.
Patrizia MAGARÒ
doaj   +2 more sources

The fiscal sustainability forecasting model in the member states of the European Union

Technological and Economic Development of Economy
This paper develops an integrated methodological framework for classifying and forecasting fiscal sustainability among the 27 Member States of the European Union, starting from a fundamental economic question: how can EU Member States’ fiscal ...
Gabriela Dobrotă, Alina Daniela Voda, Gabriela Bușan, Carina Elena Stegăroiu, Olivia-Roxana Alecsoiu, Mihaela Loredana Ecobici, Ionuț Marius Croitoru   +6 more
doaj   +1 more source

European Commission Initiatives to Promote Social Concern on the Market: a Counterbalance to Fiscal Discipline? [PDF]

Romanian Journal of European Affairs, 2014
The aim of this article is to analyse the significance of recent European Commission initiatives in the face of evidence of non-compliance with the social objectives targeted in the 2020 Strategy.
Laura Gómez Urquijo
doaj  

China's Low‐Carbon Energy Transition Over the Past Two Decades: Experiences and Implications

Advanced Science, EarlyView.
China's low‐carbon energy transition features a brief decline and subsequent rebound in coal consumption, alongside the rapid expansion of renewable energy. This study develops a stage‐based analytical framework to explain this evolution from the perspectives of economic development, energy security, and environmental sustainability, revealing how ...
Yu Liu, Zhiyu Tian, Zhengxian Zhang, Xinbei Li   +3 more
wiley   +1 more source