Results 91 to 100 of about 467,723 (245)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
A comparative analysis of EU funding and policy support structures : Report to Scotland Europa (Scottish Enterprise) [PDF]
, 2007 The study involved a comparative assessment of support structures for attracting EU funding in Finland, Sweden, Ireland, Emilia Romagna (Italy), and Nordrhein Westfalen (Germany).
Bachtler, John +2 more
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Between development and social policies: the impact of European Structural Funds in Objective 1 Regions [PDF]
European regional support has grown in parallel with European integration. The funds targeted at achieving greater economic and social cohesion and reducing disparities within the European Union (EU) have more than doubled in relative terms since the end
Andrés Rodríguez-Pose, Ugo Fratesi
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European Regional Development Policies: History and Current Issues [PDF]
, 2003 The objective of this paper is to demonstrate that the European regional development funds do not allow simultaneous achievement of goals of efficiency and equity when they are dedicated to financing transportation infrastructures.
Dall'Erba, Sandy
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The European Union budget [PDF]
This paper analyses the current budgetary system of the EU, its features and the differences in it from the budgets of nation states, particularly from the standpoint of budgetary revenue and expenditure.
Hrvoje Simovic
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Formy udziału banków w finansowaniu projektów inwestycyjnych z udziałem środków Unii Europejskiej [PDF]
, 2007 Poland has got an opportunity to partake in substantial EU funding allocated in its majority to financing investment projects. Banks can play a major role in the process of absorbing EU funding, through the supply of capital complementing investor’s own ...
Jurkowska, Anna
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Conditions for a contribution by the Structural Funds to real convergence of the Recently Acceded Member States [PDF]
The recent EU enlargement poses immense challenges for EU regional policy in terms of increased necessity of priority setting and achieving allocative efficiency.
Michael H. Stierle
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