Results 111 to 120 of about 467,723 (245)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The macroeconomic impact evaluation of the cohesion structural funds [PDF]
The National Development Plan (NDP) is the fundamental instrument by which Romania must recover as quickly as socio-economic disparities towards the EU.
Cristinel GLODEANU, Elena GLODEANU
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Task 55 Dialogue with fundersD515 D515 Webinars about EU funding programmes Year 2 to ...
openaire +1 more source
European Money at Work: Contracting a European Identity? [PDF]
Most literature on the interaction between European institutions and NGOs focuses on interest representation and lobbying. This article tackles a neglected aspect of this interaction: the effects of European funding opportunities on NGO's organizational ...
Rosa Sanchez Salgado
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Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Financing Externalisation: The Role That EU Funds Play in Shaping the Turkish Asylum and Migration Policies. [PDF]
J Immigr Refug StudUlusoy O.
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Institutional Challenges to Romania’a Regional Policy in the Perspective of Accession to the European Union [PDF]
Starting with 1998, when the process of Romania’s accession to the EU was officially launched, the legal and institutional framework for regional development policy has been created, followed by the elaboration of the National Development Plan.
Daniela-Luminita Constantin
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