Results 151 to 160 of about 468,247 (310)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

OVERCOMING ADMINISTRATIVE OBSTACLES IN FINANCING CROATIAN FARMERS AND ENTREPRENEURS: THE POLICY DIMENSION OF THE EUROPEAN UNION'S FUND ABSORPTION [PDF]

open access: yesScientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development
The research aims to analyze the EU funding for agriculture as well as the administrative obstacles of the national public bodies in using these funds for Croatian family farms/entrepreneurship and the role of policymakers in increasing the efficiency of
Marko ŠOSTAR   +2 more
doaj  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

The macroeconomic impact evaluation of the cohesion structural funds [PDF]

open access: yes
The National Development Plan (NDP) is the fundamental instrument by which Romania must recover as quickly as socio-economic disparities towards the EU.
Cristinel GLODEANU, Elena GLODEANU
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

European Money at Work: Contracting a European Identity? [PDF]

open access: yes
Most literature on the interaction between European institutions and NGOs focuses on interest representation and lobbying. This article tackles a neglected aspect of this interaction: the effects of European funding opportunities on NGO's organizational ...
Rosa Sanchez Salgado
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Webinars about EU funding

open access: yes
Task 55 Dialogue with fundersD515 D515 Webinars about EU funding programmes Year 2 to ...
openaire   +1 more source

How Does Sub-National Autonomy Affect the Effectiveness of Structural Funds? [PDF]

open access: yes
Economic and social cohesion between the EU Member States is one of the explicitly stated goals in the Treaty on European Union. The EU’s Structural Funds as a part of the Union’s regional policies are a mechanism of conditional grants that provides co ...
Cornelius Baehr
core  

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