Results 121 to 130 of about 34,270 (263)

Reforming medical device regulation in Europe: centralization, governance, and the case for an EU medical device agency. [PDF]

Lancet Reg Health Eur
Schönfelder A, Melvin T, Minssen T, Gilbert S.   +3 more
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Correction: SAVI: molecular mechanisms, clinical spectrum and precision medicine approaches beyond type-I IFN. [PDF]

Front Immunol
Manganelli M, Cantalice P, Papri J, Drago E, De Lucchi N, Accorsi G, Fresia C, Simonetti S, Guida G, Cazzato G, Mura MD, Ingravallo G, Caorsi R, Volpi S, La Torre F, Gattorno M.   +15 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Quality improvement in emergency units in low resource settings: a qualitative assessment for understanding challenges and delivering solutions. [PDF]

BMJ Open Qual
Welgama I, Lange D, O'Reilly G, Nishimwe A, Ignatowicz A, Davies J.   +5 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Every cancer patient counts: strengthening European population-based cancer registries to improve cancer control. [PDF]

Lancet Reg Health Eur
Geleijnse G, Backes C, Chirlaque MD, Sloep M, Rodon Navarro E, Šekerija M, van Eycken L, Ursin G.   +7 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

European agricultural pest management practices following the Green Deal - gaps and challenges. [PDF]

Front Insect Sci
Balog A, Loxdale HD, Csorba AB, Keszthelyi S.   +3 more
europepmc   +1 more source

The use of EU funds in Slovakia

Strategic Management, 2015
The paper investigates how funds are allocated by the European Union and how they are used in the Slovak Republic. The paper concentrates on utilizing funds in two regions: Trnava self-governing region and Presov self-governing region, in two periods, namely 2004-2006 and 2007-2013. The conclusions define some negative issues in the process of applying
openaire   +1 more source