A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
A Multidisciplinary Model for Risk Management and Detection of Ageist Bias in Healthcare Systems in the Era of Artificial Intelligence. [PDF]
Healthcare (Basel)Cohen E, Adler Y, Nissanholtz-Gannot R.
europepmc +1 more source
The Institutional Framework of the EU
, 2014 The Handbook provides an authoritative overview of the MLG literature. . . it has the potential to be widely used as a source of reference. The book is systematically structured, and most chapters are of high quality. . .' Achim Hurrelmann, Environment and Planning C 'The editors have produced an authoritative and comprehensive guide to multi-level ...
openaire +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Requirements and Implementation Challenges of Automated Outbreak Detection Systems in the European Union: Mixed Methods Study. [PDF]
JMIR Public Health SurveillVom Felde Genannt Imbusch P +4 more
europepmc +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Reframing emergency preparedness from facility survival to laboratory animal welfare. [PDF]
Lab Anim ResKim SY, Lee JM, Seok SH.
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
When institutions, technologies, and platforms co-evolve: a triadic co-evolutionary framework for public health governance in regulated digital service industries. [PDF]
Front Public HealthXiao Y, Liao Z, Zhang H.
europepmc +1 more source