Results 201 to 210 of about 3,363,783 (274)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Accelerating Research on Brain Aging: Enabling Brain Imaging Data Sharing in the Open Science Landscape. [PDF]

Eur J Neurol
Giehl K, van Eimeren T.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Landscape analysis towards data quality and utility labelling in the European Health Data Space. [PDF]

Eur J Public Health
Sánchez-García Á, Proietti Mercuri C, Schutte N, Estupiñán-Romero F, Tellería-Orriols C, Doñate-Martínez A, García-Gómez JM, Bernal-Delgado E, Sáez C, On Behalf Of Quantum.   +9 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Strengthening one health systems: A readiness assessment across Croatia, Ghana and Nigeria. [PDF]

One Health
El-Jardali F, Fadlallah R, Nuvey FS, Darwiche N, Bekavac B, Jeličić P, Delak L, Hengel B, Amuasi JH, Aglanu LM, Opoku D, Uneke J, Chukwu O, Enyi A, Romão D, Kuchenmüller T, Fahrion A.   +16 more
europepmc   +1 more source

Identifying barriers and policy priorities for rare disease research in underrepresented European countries. [PDF]

Eur J Public Health
Lace B, Inashkina I, Dan D, Weinman A, Adam P, Kvlividze O, Tumiene B, Isidro A, Pereira CA, Teixeira G, Crowley RK, ERDERA UC Stakeholder Panel.   +11 more
europepmc   +1 more source

The future of pharmaceuticals: strategic foresight in an era of uncertainty. [PDF]

J Pharm Policy Pract
Ostrovska K.
europepmc   +1 more source

EUPopLink Country report - Iceland. [PDF]

Open Res Eur
Bergmann E.
europepmc   +1 more source