Results 61 to 70 of about 5,431,686 (258)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Annals of GIS, 2019 In 2007, the European Parliament established the Directive 2007/2/EC for the Infrastructure for Spatial Information in the European Community (INSPIRE).
Kalogeropoulos Kleomenis +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
GENERAL REMARKS REGARDING THE LAWYER PROFESSION WITHIN THE EUROPEAN UNION [PDF]
Challenges of the Knowledge Society, 2013 Legal professions are generally regulated at national level. Although there may be natural similarities between them, these national regulations differ quite substantially from one country to another.
AUGUSTIN FUEREA
doaj
Data Protection in EU Financial Services. ECRI Research Report No. 6, 1 April 2004 [PDF]
, 2004 [From the Introduction] Individual privacy has always been a source of concern for common citizens, but mainly from the perspective of human rights and civil liberties.
Sousa de Jesus, Alfedo.
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Symbolon, 2020 Restriction from the Principle of Free Transmission or Retransmission Of Audiovisual Media Services in Light of the Revised Audiovisual Media Services Directive of the EU In December 2018, the revision of the Audiovisual Media Services Directive, as a ...
Zsolt Kokoly
doaj
Que peut-on attendre de la directive services ? [PDF]
L’article s’intéresse aux effets prévisibles de la Directive Services. En premier lieu il étudie les trois manières d’interpréter l’expression commerce de services : celle des Comptes nationaux, celle de la Balance des Transactions Courantes et celle de ...
Damien Broussolle
core
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source