Results 141 to 150 of about 5,086,136 (302)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
REGIONAL CONVERGENCE AND THE IMPACT OF EUROPEAN STRUCTURAL FUNDS OVER 1989-1999: A SPATIAL ECONOMETRIC ANALYSIS [PDF]
This paper estimates the impact of structural funds on the convergence process between 145 European regions over 1989-1999. Since the majority of these funds finance transportation infrastructures, they induce spillover effects, industry relocation and ...
Julie Le Gallo, Sandy Dall'erba
core
The Role and Significance of EU Funds for the Republic of Croatia
Ekonomski Vjesnik, 2013 The Republic of Croatia was granted the official candidate country status for the membership in the European Union on 18 June 2004. Thus it gained the opportunity to use pre-accession funds aimed at helping the candidates to bring their institutions and ...
Marija Tolušić +2 more
doaj
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Ireland: An Example Of Best Practices In The Utilization of EU funds [PDF]
Ireland holds the story of a successful evolution from the moment of its accession to the European Union up to the present day, achieving an impressive economic transformation that repositioned the country in the hierarchy of developed EU member states ...
Amalia Nicoleta Coman, Paul Coman
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
EU Development Policies and the Socio-Economic Disadvantage of European Regions. [PDF]
The debate over the EU budget 2007-2013 made clear the need of an in-depth understanding of the distribution of the EU development funds. The scarce resources available need to be targeted more effectively towards the real needs of EU countries and ...
Riccardo Crescenzi
core
European integration and the Dutch disease: Portugal and Spain
RUDN Journal of Economics, 2013 Portuguese and Spanish economies received large sums from the European structural funds and used the significant reduction in interest rates on loans after joining the EU.
J S Andrade, A P Duarte
doaj