Results 201 to 210 of about 227,974 (244)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

You aren't going to like what comes after America: Europe and global health after 2025. [PDF]

Eur J Public Health
Greer SL.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Synergistic Photophysical and Mechanical Enhancement in Europium Supramolecular Hydrogel by Incorporating Gd(DPA)₃ Complex (DPA = Dipicolinate). [PDF]

ChemistryOpen
Cavalcante CO, Pereira SCF, Malta SHS, Silva JYR, B W, Luz LLD, da Silva JAB, Júnior SA.   +7 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Edible Insects: Food Safety Challenges and Regulatory Perspectives. [PDF]

Foods
Silva SAM, Esteves VT, Ribeiro T, Andrade J, Couto C, Prata JC.   +5 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Assessment of predictive value of pre- and postoperative urethral pressure profiles for long-term continence in female dogs with ectopic ureters: a preliminary study. [PDF]

Acta Vet Scand
Langer P, Hamaide A, Noël S.
europepmc   +1 more source

Extensive variation between chromosomes of North American and European hop. [PDF]

Nat Commun
Kale SM, Gundlach H, Gericke O, Kamal N, Almeida A, Pitra N, Price N, Haberer G, Lux T, Krsticevic F, Kemp O, de Bang L, Himmelbach A, Padmarasu S, Rabanus-Wallace MT, Horáková L, Bačovský V, Nielsen K, Bjarnholt N, Micic N, Kruse-Andersen I, Møller BL, Janfelt C, Skadhauge B, Matthews PD, Mayer KFX, Stein N, Mascher M, Spannagl M, Feiner A, Braumann I.   +30 more
europepmc   +1 more source

Urbach Energy: Film Processing and Thickness Effects. [PDF]

Langmuir
de Azevedo MMF, Costa EEC, de Araújo GSM, de Carvalho KMP, da Luz Lima C, Hidalgo ÁA, Vega ML.   +6 more
europepmc   +1 more source