Results 51 to 60 of about 495,115 (315)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Survival probability and order statistics of diffusion on disordered media

, 2002
We investigate the first passage time t_{j,N} to a given chemical or Euclidean distance of the first j of a set of N>>1 independent random walkers all initially placed on a site of a disordered medium.
A. Bunde, G.H. Weiss, G.M. Sastry, H. Larralde, H. Larralde, H.E. Roman, H.E. Roman, H.E. Roman, I. Majid, J. Dräger, J. Klafter, J.W. Essam, L. Acedo, L. Acedo, L. Acedo, M. Giona, M.F. Shlesinger, M.T. Valentine, P.L. Krapivsky, P.L. Leath, R. Metzler, S. B. Yuste, S. Havlin, S. Havlin, S. Redner, S.B. Yuste, S.B. Yuste, S.B. Yuste, S.B. Yuste, S.B. Yuste, S.B. Yuste, S.B. Yuste, S.B. Yuste, S.B. Yuste, U. Mosco, X.S. Xie, X.S. Xie   +36 more
core   +1 more source

Approximation of the Euclidean Distance by Chamfer Distances

Acta Cybernetica, 2012
Preprint submitted to Acta Cybernetica, 20 ...
András Hajdu, Lajos Hajdu, Robert Tijdeman   +2 more
openaire   +3 more sources

Euclidean Distance Degree of Projective Varieties [PDF]

International Mathematics Research Notices, 2019
Abstract We give a positive answer to a conjecture of Aluffi–Harris on the computation of the Euclidean distance degree of a possibly singular projective variety in terms of the local Euler obstruction function.
Maxim, Laurentiu G., Rodriguez, Jose Israel, Wang, Botong   +2 more
openaire   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Properties of Energy-Like Statistics Under Squared Euclidean Distance and Exponential Gamma Distributions [PDF]

BIO Web of Conferences
This study investigates distance-based statistical parameters and squared Euclidean distance for samples from exponential and gamma distributions. Statistical tests can be used as two-sample tests to determine the homogeneity between the distributions of
Jebur Ali Ahmed, Ali Naji Abeer, Hussein Abd Zaid Baneen, Hataf Fazaa Kawthar, Ramadhan Ali J.   +4 more
doaj   +1 more source

Coordinate shadows of semi-definite and Euclidean distance matrices [PDF]

, 2015
We consider the projected semi-definite and Euclidean distance cones onto a subset of the matrix entries. These two sets are precisely the input data defining feasible semi-definite and Euclidean distance completion problems.
Drusvyatskiy, D., Pataki, G., Wolkowicz, H.   +2 more
core   +3 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The Euclidean distance degree of an algebraic variety [PDF]

, 2013
The nearest point map of a real algebraic variety with respect to Euclidean distance is an algebraic function. For instance, for varieties of low rank matrices, the Eckart-Young Theorem states that this map is given by the singular value decomposition ...
Draisma, Jan, Horobet, Emil, Ottaviani, Giorgio, Sturmfels, Bernd, Thomas, Rekha R.   +4 more
core   +2 more sources