Results 21 to 30 of about 2,244 (146)

Metabolic and Inflammatory Adverse Drug Reactions Associated with Amlodipine: A Descriptive and Disproportionality Analysis of EudraVigilance Reports [PDF]

Pharmaceuticals
Background/Objectives: The global rise in obesity-related hypertension, metabolic syndrome, and chronic inflammation calls for a precise characterization of the safety profiles of first-line therapies. While amlodipine is considered metabolically neutral,
Crina Cristina Solomon, Anca Butuca, Adina Frum, Carmen Maximiliana Dobrea, Claudiu Morgovan, Nastaca Alina Palade, Alina Liliana Pintea, Dragoș Anton Dădârlat, Steliana Ghibu, Florina Batar, Mariana Cornelia Tilinca, Felicia Gabriela Gligor   +11 more
doaj   +2 more sources

Comparison Study of the Safety Profile of Olaparib Versus Niraparib: Analysis of Real-World Data from EudraVigilance

Pharmaceuticals
Background: Olaparib and niraparib are poly (ADP-ribose) polymerase inhibitors (PARPi) used primarily for the treatment of ovarian cancer. While both drugs have demonstrated efficacy in clinical trials, their safety profiles, particularly in real-world ...
Desirèe Speranza, Fausto Omero, Vincenzo Cianci, Mariapia Marafioti, Carla Infurna, Patrizia Carroccio, Edoardo Spina, Maria Antonietta Barbieri, Emanuela Esposito, Nicola Silvestris, Mariacarmela Santarpia   +10 more
doaj   +2 more sources

Study of epinephrine-induced cardiovascular adverse events in patients with anaphylaxis using two spontaneously reported adverse event databases from 2004 to 2024 [PDF]

Scientific Reports
Anaphylaxis is a life-threatening hypersensitivity reaction requiring prompt administration of epinephrine. Despite its life-saving role, hesitancy in epinephrine use persists, largely due to concerns about cardiovascular adverse events (AEs). This study
Priyanka Kamath, Rashmi R. Rao, Ashwin Kamath   +2 more
doaj   +2 more sources

Exploratory Signal Detection of Maternal and Perinatal Adverse ART Drug Events in EudraVigilance: Insights from Network and Cluster Analyses

Pharmacoepidemiology
Background: Medication safety in pregnancy, puerperium, and perinatal periods is underexplored because these populations are excluded from clinical trials.
Bárbara Costa, Nuno Vale
doaj   +2 more sources

Divergent System Organ Class Safety Profiles of Isotretinoin Versus Topical Retinoids: An EudraVigilance Disproportionality Analysis [PDF]

Pharmaceuticals
Background/Objectives: Isotretinoin remains an essential therapy for severe acne, yet its safety profile continues to raise concerns. This study analyzed adverse event reporting patterns for isotretinoin versus topical retinoids using EudraVigilance data.
Denisa Viola Szilagyi, Delia Mirela Tit, Ruxandra Cristina Marin, Gabriela S. Bungau, Mirela Marioara Toma, Manuela Bianca Pasca, Daniela Gitea, Laura Maria Endres   +7 more
doaj   +2 more sources

Disproportionality Analysis of the Five Most Widespread Neurological Effects of COVID-19 Vaccines from 2021 to 2023: Insights from EudraVigilance

Pharmaceuticals
Background/Objectives: Post-market surveillance of COVID-19 vaccines is vital. This study analyzed EudraVigilance data (Jan 2021–Dec 2023) to detect potential safety signals linking COVID-19 vaccines and specific neurological adverse events (aseptic ...
Arturo Gómez López de las Huertas, Stefan Stewart, Mikel Urroz Elizalde, Javier Guijarro-Eguinoa, Enrique Seco-Meseguer, Elena Diago-Sempere, María Jiménez González, Antonio J. Carcas-Sansuan, Alberto M. Borobia Pérez, Elena Ramírez   +9 more
doaj   +2 more sources

Patterns of Spontaneous Adverse Drug Reaction Reporting in Germany From 2012 to 2021. [PDF]

Pharmacol Res Perspect
ABSTRACT The absolute number of spontaneous adverse drug reaction (ADR) reports increased in the past in several national and international ADR databases. However, in most studies drug exposure was not considered. Our study aimed to evaluate the number of ADR reports from Germany in relation to the number of patients with outpatient drug prescriptions ...
Dubrall D, Domgörgen S, Christ P, Below M, Schmid M, Sachs B.   +5 more
europepmc   +2 more sources

Pharmacovigilance on cannabidiol as an antiepileptic agent

Frontiers in Pharmacology, 2023
Introduction: Cannabidiol (CBD) is an active chemical contained in the plant Cannabis sativa. It is a resorcinol-based compound that crosses the blood-brain barrier without causing euphoric effects.
Ilaria Ammendolia, Carmen Mannucci, Luigi Cardia, Gioacchino Calapai, Sebastiano Gangemi, Emanuela Esposito, Fabrizio Calapai, Fabrizio Calapai   +7 more
doaj   +1 more source

Comparative Analysis of International Databases of Adverse Drug Reactions

Безопасность и риск фармакотерапии, 2020
In 1968 the World Health Organisation initiated the development of an international programme for collection of data from the maximum number of sources about potential adverse effects of medicines.
A. S. Kazakov, M. A. Darmostukova, T. M. Bukatina, N. Yu. Velts, R. N. Alyautdin   +4 more
doaj   +1 more source

European Safety Analysis of mRNA and Viral Vector COVID-19 Vaccines on Glucose Metabolism Events

Pharmaceuticals, 2022
Few data have been published on the effects of impaired glucose metabolism induced by COVID-19 vaccines. We decided to perform a study to describe Individual Case Safety Reports (ICSRs) of impaired glucose metabolism events reported in the European ...
Gabriella di Mauro, Annamaria Mascolo, Miriam Longo, Maria Ida Maiorino, Lorenzo Scappaticcio, Giuseppe Bellastella, Katherine Esposito, Annalisa Capuano   +7 more
doaj   +1 more source