The graphical abstract summarizes the current evidence on the potential neuroprotective effects of tirzepatide (TZP), a dual GIP/GLP‐1 receptor agonist, across mechanistic, preclinical, and clinical domains. Mechanistically, TZP is proposed to exert direct neural effects, preserve mitochondrial function, reduce apoptosis, oxidative stress, and ...
Yousef Hawas +6 more
wiley +1 more source
ABSTRACT Background The inflammatory response to whole‐body ischemia, as seen in comatose survivors after out‐of‐hospital cardiac arrest (OHCA), is associated with increased morbidity and mortality. Early high‐dose dexamethasone may dampen the inflammatory response, which may diminish secondary brain damage and other organ injury and decrease mortality.
Jo B. Andreasen +12 more
wiley +1 more source
Analysis of adverse event reporting patterns following COVID-19 vaccination: findings from VigiAccess, FAERS and EudraVigilance databases with comparative assessment of data representation and categorization across three databases [PDF]
The clinical presentation of COVID-19 varied from mild to severe or fatal illness, and vaccination played a pivotal role in preventing the spread of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). Despite cumulative evidence suggesting that
Bhave, Kiran A. +3 more
core +1 more source
ABSTRACT Background Delirium is a frequent complication in comatose Out‐of‐Hospital Cardiac Arrest (OHCA) survivors requiring postresuscitation intensive care and is associated with higher mortality and longer hospitalization. Despite this, there is no established pharmacologic strategy for delirium prevention in OHCA survivors.
Benedikte Liebetrau +12 more
wiley +1 more source
Comparison of adverse drug reactions among four COVID-19 vaccines in Europe using the EudraVigilance database: Thrombosis at unusual sites [PDF]
Background: Real-world experience with adenoviral vector vaccines against COVID-19 raised some safety concerns. Cases of cerebral vein thrombosis (CVT) associated with thrombocytopenia have been observed after the first dose of the adenoviral vector ...
Abbattista M. +2 more
core +1 more source
Clinical scenario Canine osteoarthritis (OA) is a degenerative joint disease and is one of the most common chronic conditions in dogs and other species. The management of OA remains a longstanding focus in veterinary medicine. Traditionally, nonsteroidal anti‐inflammatory drugs (NSAIDs) have been the first‐line treatment option for canine OA. Recently,
X Yang, P Macarthur
wiley +1 more source
Supplemental Material for Dilemma of belimumab therapy (dis)continuation during pregnancy: Results of a retrospective study in eudravigilance by Nafise Ghalandari, Hubertina JMJ Crijns, Radboud JEM Dolhain, Johanna MW Hazes and Eugene P van Puijenbroek ...
Eugene P van Puijenbroek (14202294) +4 more
core
Does additional monitoring status increase the reporting of adverse drug reactions? An interrupted time series analysis of EudraVigilance data:An interrupted time series analysis of EudraVigilance data [PDF]
Purpose: To evaluate the impact of including a medicine in the list of medicinal products subject to additional monitoring (AM) on the reporting of adverse drug reactions (ADRs) in the european economic area (EEA).Methods: Interrupted time series using ...
Arlett, P. +11 more
core +1 more source
Association Between Glucagon‐Like Peptide‐1 Receptor Agonists and Suicidality: A Systematic Review
ABSTRACT Aims We aimed to examine the association between GLP‐1 RA use and suicidal ideation or behaviours through a systematic review of observational studies. Materials and Methods A comprehensive search of MEDLINE, PubMed, EMBASE, CINAHL and PsycINFO was conducted from database inception through December 11, 2025. Observational studies investigating
Timothy H. Chan +5 more
wiley +1 more source
Association of Glucagon‐Like Peptide‐1 Receptor Agonists and Suicidality: A Systematic Review
ABSTRACT Introduction Increased risk of suicidality has been reported in association with glucagon‐like peptide receptor agonist (GLP‐1 RA) prescription. Herein, we conducted a comprehensive review evaluating reports of GLP‐1 RA prescription and suicidality.
Hezekiah C. T. Au +9 more
wiley +1 more source

