Results 131 to 140 of about 323,302 (289)
British Journal of Haematology, EarlyView.Summary Mature T‐cell lymphomas comprise a heterogeneous group of aggressive non‐Hodgkin lymphomas with limited therapeutic options in the relapsed or refractory setting. Among them, anaplastic lymphoma kinase (ALK)‐positive anaplastic large cell lymphoma (ALCL) represents a biologically distinct subtype driven by constitutive activation of ALK fusion ...
Santino Caserta +13 more
wiley +1 more source
British Journal of Haematology, EarlyView.Summary ETV6‐related thrombocytopenia (ETV6‐RT) is an inherited platelet disorder caused by germline ETV6 variants. Despite recent progress, the mechanisms underlying platelet dysfunction in ETV6‐RT remain unclear. We investigated 12 patients from six families using functional assays, electron microscopy, quantitative proteomics and cytoskeletal ...
Ivan P. Tesakov +15 more
wiley +1 more source
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary The AWMF S1 guideline 013/056 “Occupational Skin Products: Protective Creams, Skin Cleansers and Skin Care Products” from 2014 has been revised and upgraded to S2K level. The aim was to develop a decision aid for the optimal use of occupational skin products for the prevention of hand eczema in the workplace.
Michal Gina +16 more
wiley +1 more source
Disproportional ventilatory response to incremental exercise in individuals with cerebral palsy
Developmental Medicine &Child Neurology, EarlyView.Individuals with cerebral palsy demonstrate a disproportionate ventilatory response during incremental exercise. Compared with typically developing peers, respiratory frequency increases earlier and at comparable exercise intensities, contributing to higher perceived exertion and reduced ventilatory efficiency. At task failure, respiratory frequency is
Linnéa Corell +14 more
wiley +1 more source
Agricultural transition and integration to the world economy: NIS case [PDF]
The paper studies the major trends in the agri-food trade in the NIS countries. It describes the trade flows, production cooperation and trade regimes within NIS countries; trade with the rest of the world and accession to the WTO.
Serova, Eugenia
core +1 more source
Targeting Ikaros and Aiolos: Next‐Generation Cereblon E3 Ligase Modulators in MM
European Journal of Haematology, EarlyView.The graphical abstract illustrates the mechanism of action of cereblon E3 ligase modulators (CELMoDs) in multiple myeloma, highlighting cereblon‐mediated degradation of IKZF1 and IKZF3. Compared with classical immunomodulatory drugs (IMiDs), CELMoDs induce deeper IKZF1/3 depletion, leading to more pronounced suppression of the IRF4–MYC survival axis ...
Maria Eugenia Alvaro +12 more
wiley +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Primary refractory Diffuse Large B‐Cell Lymphoma is associated with poor outcomes and limited responsiveness to conventional salvage therapies. Although CAR T‐cell therapy represents the standard of care in this setting, a substantial proportion of patients cannot receive it despite meeting disease‐related criteria. In this review, “unsuitable”
Santino Caserta +12 more
wiley +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Relapsed and refractory multiple myeloma (RRMM) remains associated with poor outcomes, particularly in patients exposed or refractory to proteasome inhibitors, immunomodulatory agents, and anti‐CD38 monoclonal antibodies. Targeting B‐cell maturation antigen (BCMA) has emerged as an effective therapeutic strategy, prompting the development of ...
Maria Eugenia Alvaro +12 more
wiley +1 more source
An Organic Nation: State-Run Tourism, Regionalism, and Food in Spain, 1905–1931 [PDF]
, 2014 Afinoguénova, Eugenia
core +2 more sources