Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo +6 more
wiley +1 more source
Undergraduate Endodontic Teaching in Dental Schools Around the World: A Narrative Review. [PDF]
Segura Egea JJ +5 more
europepmc +1 more source
Genetic risk variants for multiple sclerosis are linked to differences in alternative pre-mRNA splicing. [PDF]
Putscher E +7 more
europepmc +1 more source
Mandatory Audits of Private Companies
ABSTRACT We examine mandatory audits using Spanish private companies to generate insight into (1) how audit thresholds vary in tightness and impact, (2) which audit thresholds are crossed to cause audit commencement and cessation, (3) whether firms take actions to avoid audits and (4) whether audits provide economic benefits.
Darren Henderson +2 more
wiley +1 more source
Endocrine-related adverse conditions in patients receiving immune checkpoint inhibition: an ESE clinical practice guideline. [PDF]
Husebye ES +11 more
europepmc +1 more source
The Return of Industrial Policy in the EU: A Chance for Central and Eastern Europe?
Abstract This contribution explores the Visegrad four's (V4) responses to the revival of industrial policy in the European Union (EU). To a region so highly industrialised, and so dependent on foreign firms, this revival brings mixed blessings. Industrial policy focused on ‘European champions’ is driving investment towards core regions and firms ...
Vera Šćepanović, Imre G. Szabó
wiley +1 more source
Real-world performance and accuracy of stress echocardiography: the EVAREST observational multi-centre study. [PDF]
Woodward W +45 more
europepmc +1 more source
Eurocrats Wanted: Why Some Member States Lag in European Commission Recruitment
Abstract The article investigates the underrepresentation of certain member states within the European Commission (EC) and explores the broader challenges of achieving geographical balance in European Union (EU) recruitment. Drawing on the theory of representative bureaucracy, the study systematises factors that shape the attractiveness of EU careers ...
Jarolím Antal +2 more
wiley +1 more source
Impact of sub-basalt thrust systems on the Faroe continental shelf for the late Paleoproterozoic-Cenozoic tectonic evolution of the margin. [PDF]
Koehl JP +4 more
europepmc +1 more source
Health status of a migrant population: a survey within an Extraordinary Reception Centre in Parma, Northern Italy. [PDF]
Mazzoli R +7 more
europepmc +1 more source

