Results 191 to 200 of about 5,879,476 (365)

Protecting the mental health of youth

open access: yesThe Lancet Regional Health. Europe, 2022
The Lancet Regional Health– Europe
doaj  

The Global Game has changed: What Role for Europe-Africa Relations? [PDF]

open access: yes, 2014
This publication approaches some of the issues involved in the reshaping of EU-Africa relations in the recent past and for the next few years. Several authors, from Europe and from Africa, assess the partnership’s achievements so far and also the ...
Europe Africa Research Network
core  

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

open access: yesFEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang   +7 more
wiley   +1 more source

The Vaccinated and unvaccinated need to coexist with tolerance and respect

open access: yesThe Lancet Regional Health. Europe, 2022
The Lancet Regional Health – Europe
doaj  

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

open access: yesFEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma   +3 more
wiley   +1 more source

Enhancing foundation models for scientific discovery via multimodal knowledge graph representations

open access: yesWeb Semantics
Foundation Models (FMs) hold transformative potential to accelerate scientific discovery, yet reaching their full capacity in complex, highly multimodal domains such as genomics, drug discovery, and materials science requires a deeper consideration of ...
Vanessa Lopez   +8 more
doaj  

Heavy metals and nitrogen in mosses: spatial patterns in 2010/2011 and long-term temporal trends in Europe [PDF]

open access: yes, 2013
Naturally-occurring mosses have been sampled across Europe to monitor the deposition of heavy metals and nitrogen from the air. This survey has been repeated at five-yearly intervals since 1990 for heavy metals and since 2005 for nitrogen.
Harmens, Harry   +2 more
core  

A non‐fluorescent immunohistochemistry method for measuring autophagy flux using MAP1LC3/LC3 and SQSTM1 as core markers

open access: yesFEBS Open Bio, EarlyView.
We introduce an immunohistochemistry method to measure autophagy flux, highlighting the active degradation and recycling of cellular waste. This cost‐effective approach uses tissue samples to track key markers like LC3 and SQSTM1, revealing how cells maintain health or respond to diseases such as cancer. It bridges the gap between research and clinical
Shahla Shojaei   +6 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

open access: yesFEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik   +3 more
wiley   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

open access: yesFEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang   +9 more
wiley   +1 more source

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