Results 31 to 40 of about 734,641 (266)

Economic Policy Co-ordination and Policy Regimes in the European Union [PDF]

Romanian Journal of European Affairs, 2002
In this article, it is argued that coordination of economic policies in the European Union has not led to a weakening of the role of the nation states in shaping their own economic policies.
Stefano Micossi
doaj  

Long-term, Prolonged-release Tacrolimus-based Immunosuppression in De Novo Liver Transplant Recipients: 5-year Prospective Follow-up of Patients in the DIAMOND Study

Transplantation Direct, 2021
Background. Immunosuppression with calcineurin inhibitors (CNIs) is reportedly associated with risk of renal impairment in liver transplant recipients.
Styrbjörn Friman, MD, PhD, Giuseppe Tisone, MD, Frederik Nevens, MD, PhD, Frank Lehner, MD, Walter Santaniello, MD, Wolf O. Bechstein, MD, PhD, Sergey V. Zhuvarel, MD, Helena Isoniemi, MD, PhD, Oleg O. Rummo, MD, Jürgen Klempnauer, MD, Swapneel Anaokar, MBBS, MD, Martin Hurst, MBBS, FRCP, Gbenga Kazeem, PhD, Nasrullah Undre, PhD, Pavel Trunečka, MD, PhD   +14 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Hemochromatosis: A Risk Factor for Breast Cancer? Systematic Review and Meta-Analysis

European Journal of Breast Health
Objective: Hereditary hemochromatosis and breast cancer are two major public health problems. The HFE gene variants C282Y and H63D, responsible for most cases of hemochromatosis, may contribute to carcinogenesis via iron overload, oxidative stress, and ...
Megane Buttignol, Caroline Bouche, Manon Chrétien, Nicolas Taris, Tolga Ozmen, Carole Mathelin   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Remarks on the Future of the European Union: Domestic and Global Challenges Ahead [PDF]

Romanian Journal of European Affairs, 2011
This paper highlights the main consequences that the crisis has put on the European Union, regarding four major areas: financial, macroeconomic, social and mental-ideological.
András Inotai
doaj  

Between the general and specific: Political tolerance and general support for democracy in Serbia and Europe [PDF]

Sociologija, 2008
Political tolerance is one of the basic values of a democratic society. At the same time, it is also a controversial value - political freedoms are often used to undermine democratic order.
Todosijević Bojan
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source