The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
A Bottom-up Look at Mutual Trust and the Legal Practice of the Aranyosi Test
This contribution offers an insight into the legal practice of the Aranyosi test during the EAW proceedings in seven Member States, an outcome of the research conducted during the ImprovEAW Project.
Christina Peristeridou
doaj +1 more source
Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito +8 more
wiley +1 more source
The problem with implementation of human rights in the execution of European arrest warrant
In this paper, the author will deal with practical cases from execution of the European arrest warrant. Often there is a negation of the rules in practice, in the matters of EAW the most common violations are inhumane conditions in prisons and disregard ...
Bojana Zimonjić
doaj +1 more source
Application of the European Arrest Warrant by the Polish Law Enforcement [PDF]
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Tomasz Słapczyński
doaj +1 more source
Objective Despite well‐described biologic causes, the public views unhealthy lifestyle choices as the primary cause of gout. This study investigated how causal beliefs about gout influence the public's views about its management. Methods In a randomized study, 201 members of the public viewed one of two 2‐minute videos about gout.
Rachel Murdoch +6 more
wiley +1 more source
Managing diversity: The European Arrest Warrant and the potential of mutual recognition as a mode of governance in EU Justice and Home Affairs [PDF]
[From the introduction]. Mutual recognition is the central mode of governance in the Single Market which helped to overcome trade barriers caused by differences in national product regulation.
Sievers, Julia.
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Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin +14 more
wiley +1 more source
Judicial Cooperation in Criminal Matters - European Arrest Warrant – A Good Testing Ground for Mutual Recognition in an Enlarged EU? CEPS Policy Briefs No. 46, February 2004 [PDF]
This paper reviews the extent to which the development of instruments that implement the principle of mutual recognition of judicial decisions in criminal matters, particularly the European arrest warrant (EAW), may be considered valuable tools for ...
Carrera, Sergio., Apap, Joanna
core

