Results 21 to 30 of about 3,259,672 (304)
European Defence Community: origins of integration in the defence sphere
Проблеми Законності, 2017 There is a tendency among non-historians to force «practioners» of the discipline to justify why the study of a particular episode of the past is so important and to articulate the lessons to be learned from the experience.
Іван Васильович Яковюк +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Rail Policy in the European Community. [PDF]
, 1991 This paper begins by considering the reasons why the rail sector has long been considered a problem in European transport policy. These concern both the degree of government intervention and subsidy, which conflicts with the aim of a free international ...
Nash, C.A.
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Foreword On the Occasion of the Five-Year Anniversary… [PDF]
Romanian Journal of European Affairs, 2005 We celebrate the five-year anniversary of the European Institute of Romania with the feeling of having accomplished several projects that contributed to Romania’s preparation for its accession to the European Union. What do five years mean? An important
Niculae Idu
doaj
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Air transport liberalisation in the European Union and its impact on development of the civil aviation sector in Poland [PDF]
, 2009 The objective of this paper is to present an overview of the process of air transport liberalisation within the European Community and its influence on development of the aviation market in Poland.
Pisarek-Bartoszewska, Renata
core +2 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Background and formation of cooperation between European Union member states in the field of defense
Теорія і практика правознавства, 2019 The historical way of development of integration processes in the defence sphere, starting with the end of World War II up to nowadays, appeared to be rather complicated.
Юлія Володимирівна Петренко
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source