Results 31 to 40 of about 632,939 (308)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Anali Hrvatskog Politološkog Društva, 2006 The basic argument of the article is that the main causes of failure of the European Constitution stem from an inadequate preparation and implementation of a complex procedure of constitution-making for a federation of countries on a continental scale ...
Robert Podolnjak
doaj
Political legitimacy and European monetary union: contracts, constitutionalism and the normative logic of two-level games [PDF]
, 2015 The crisis of the euro area has severely tested the political authority of the European Union (EU). The crisis raises questions of normative legitimacy both because the EU is a normative order and because the construction of economic and monetary union ...
Bellamy, R, Weale, A
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Governance and ”European Constitution”
Transylvanian Review of Administrative Sciences, 2008 The aim of this paper is to explain concepts like governance and good governance and to analyse to what degree can we talk about an efficient governance within the European Union.
Adrian IVAN
doaj
The EU’s neoliberal constitutionalism(s)
European Law OpenBeyond their differences, the various currents of neoliberalism share a common legal agenda: economic constitutionalism. From ordoliberal Ordnungspolitik to new classical macroeconomics and public choice, from Hayek’s ‘constitution of liberty’ to Vanberg’
Guillaume Grégoire
doaj +1 more source
European Constitutional Language [PDF]
, 2016 If the task of constitutional theory is to set out a language in which the discourse of constitutional law may be grounded, a question of the utmost importance is how this terminology is created, defined and interpreted. In this groundbreaking new work, András Jakab maps out and analyses the grammar and vocabulary on which the core European traditions ...
openaire +1 more source
United Kingdom judges and European integration [PDF]
, 2015 The British, specifically the English, are widely regarded as awkward partners in the European project. Much of the criticism has come from anti-European integration politicians.
Birkinshaw, Patrick
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source