Results 71 to 80 of about 632,494 (309)

Masterclass: international law and constitutional development in 19th century Europe (Part II) [PDF]

, 2015
1. Today, Hungary is a small Central-Eastern-European country making headlines with its domestic political and constitutional controversies. Yet, throughout its 1000-year history, this country had many struggles and developments, which, when put into a ...
Beke-Martos, Judit
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

From Austerity to Solidarity: How Deviations Preserve the EU’s Macro-Constitution

European Constitutional Law Review
Treaties of the European Union – Comprehensive framework for macro-economic governance, devoid of democratic influence – Divergence from this seemingly stringent framework during the Euro Crisis and the Covid-19 pandemic – Pattern of deviation from the ...
Hilary Hogan
doaj   +1 more source

Europejska filozofia praw człowieka a konstytucyjna formuła obowiązków człowieka i obywatela

Filozofia Publiczna i Edukacja Demokratyczna, 2018
This article is devoted to the problem of the obligations of a human and citizen in the Polish constitution. This matter is shown from the philosophy and legal point of you.
Bartosz Liżewski
doaj   +1 more source

Constitutional Supremacy: National Constitutions vs. European Law

Australian and New Zealand Journal of European Studies, 2011
CESAA 18TH ANNUAL EUROPE ESSAY COMPETITION 2010 - Postgraduate winner: Vanessa McGlynn, University of New South WalesAlmost 50 years after the European Court of Justice clearly established the supremacy of Community law, the question regarding the primacy of law within the European context remains unresolved.
openaire   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The European Constitutional Settlement [PDF]

The World Economy, 2007
This paper argues first that a synthesis of the theories of endogenous policy formation, non‐coercive interstate bargaining theory, and international regime theory provides a plausible account of the path of European integration, with little role for explanations stressing geopolitical or ideological factors, international mediation, or political ...
openaire   +1 more source

European Environmental Law and the Constitution [PDF]

, 2003
The author describes how the European Union sought to institute environmental protection through the development of the constitution and the rights it guarantees such as the right to a healthy ...
Kiss, Alexandre
core   +2 more sources