Results 71 to 80 of about 632,939 (308)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The Latvian direct democracy tools in a comparative European context
Oñati Socio-Legal Series, 2019 This article analyses and compares the legal tools of direct democracy in Latvia and other European countries. Based on comparison, the author draws concludes the shortcomings of the legal framework of direct democracy in the Constitution of the Republic
Fabio Ratto Trabucco
doaj +1 more source
Masterclass: international law and constitutional development in 19th century Europe (Part II) [PDF]
, 2015 1. Today, Hungary is a small Central-Eastern-European country making headlines with its domestic political and constitutional controversies. Yet, throughout its 1000-year history, this country had many struggles and developments, which, when put into a ...
Beke-Martos, Judit
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Historia.scribere, 2012 The following seminar-paper compares two constitutions and one concept of a constitution from the end of the 18th century. Considering the first French constitution, the Constitution Française from 1791, the first “modern” European constitution, the ...
Alexander Piff
doaj +2 more sources
TalTech Journal of European StudiesThe 2017–2018 constitutional reform amended the Constitution of Georgia and changed the political system of the country. The president has the responsibility to represent the country in international relations, but only with the approval of the ...
Gegenava Dimitry, Goradze George
doaj +1 more source
Constitutional Supremacy: National Constitutions vs. European Law
Australian and New Zealand Journal of European Studies, 2011 CESAA 18TH ANNUAL EUROPE ESSAY COMPETITION 2010 - Postgraduate winner: Vanessa McGlynn, University of New South WalesAlmost 50 years after the European Court of Justice clearly established the supremacy of Community law, the question regarding the primacy of law within the European context remains unresolved.
openaire +3 more sources
The European Constitution: past and future [PDF]
, 2003 Does Europe need a Constitution? This is the question that has attracted the attention of observers of the European scene, especially lawyers and political scientists, ever since the debate over Giscard d'Estaing's draft Constitution revived public ...
Puig, Gonzalo Villalta
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source