Results 81 to 90 of about 632,494 (309)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

The European Union in Transition: The Treaty of Nice in Effect; Enlargement in Sight; A Constitution in Doubt [PDF]

open access: yes, 2003
This Article is intended to provide an overview of this transitional moment in the history of the European Union. Initially, the Article will briefly review the background of the Treaty of Nice, and the institutional structure modifications for which it ...
Goebel, Roger J.
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Article 93 as a European clause in the Spanish Constitution

open access: yesEastern European Journal of Transnational Relations
The purpose of this article is to answer the question of the legal nature of the European clause contained in the Spanish Constitution. The article examines how it has influenced the process of European integration and the constitutional order in that ...
Andrzej Jackiewicz
doaj   +1 more source

The Importance of Being Nice: An Institutionalist Analysis of French Preferences on the Future of Europe [PDF]

open access: yes
This article offers an institutionalist explanation of French preferences on the future of Europe from the Maastricht Treaty of 1992 through the Constitutional Treaty of 2004. It argues that the autonomous institutional logic of the constitution-drafting
Nicolas Jabko
core  

"Decision Making in Europe: Were Spain and Poland Right to Stop the Constitution in December 2003?" [PDF]

open access: yes, 2005
This paper tries to explain why Spain and Poland stopped the Draft Constitution for the European Union in December 2003 and discusses whether this action was compatible with these countries long term interests. The author finds that the decline in power –
Ade, Florian.
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Subsidiarity under the Constitution for Europe [PDF]

open access: yes, 2006
The principle of subsidiarity lies at the heart of the European Union’s strife to bring the EU closer to the citizen. Yet, it appears to be failing to do so in its present form. Therefore, the new Treaty Establishing a Constitution for Europe [hereafter:
Goudappel, F.A.N.J. (Flora)
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Verfassungen für ein modernes Europa? Untersuchungen zu Konstitutionalisierungsprozessen in Frankreich, Polen-Litauen und im Großherzogtum Toskana am Ende des 18. Jahrhunderts. Vergleich und Analyse

open access: yesHistoria.scribere, 2012
The following seminar-paper compares two constitutions and one concept of a constitution from the end of the 18th century. Considering the first French constitution, the Constitution Française from 1791, the first “modern” European constitution, the ...
Alexander Piff
doaj  

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