Results 201 to 210 of about 9,938 (255)

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

The United Nations convention on rare diseases-A framework for research prioritization. [PDF]

Front Public Health
Junaid M, Downs J, Groza T, Lassmann T, Baker S, Stevens K, Keeffe J, Gration D, Newell A, Duckers J, Baynam G.   +10 more
europepmc   +1 more source

Wearable‐Derived Diurnal Alignment Between Physical Activity and Device Temperature Predicts Future Disease and Mortality Risk

Advanced Science, EarlyView.
Wearable‐derived diurnal alignment between physical activity and device temperature, decomposed into 24 h coupling strength (M24), phase deviation (D24), and 12 h harmonic magnitude (M12), is examined in approximately 90,000 UK Biobank participants.
Han Chen, Jiahe Wei, Jonathan Cedernaes, Christian Benedict, Athanasios Tsanas, Zhi Cao, Xiao Tan   +6 more
wiley   +1 more source

The risk of digital defencelessness arising from generative artificial intelligence. [PDF]

Front Psychol
Martín Y Ladera I, Martínez-Ruiz MP, Araque-Hontangas N.   +2 more
europepmc   +1 more source

Human Rights as Justifications in Wildernesses: A Third World Approach to EU Law. [PDF]

Jus Cogens
Ganesh A.
europepmc   +1 more source

Reframing involuntary treatment as a sentinel event: a model for improving rights-based mental health care. [PDF]

Front Psychiatry
Cossu G, Atzeni M, Zreik T, Tusconi M, Carta MG.   +4 more
europepmc   +1 more source

Enslaving Minds: On Freedom of Thought and the Exploitation of Mental Vulnerabilities. [PDF]

Neuroethics
Ligthart S.
europepmc   +1 more source

Indigenous Knowledge Systems & Psychedelic Science: Towards Ethical and Reciprocal Collaboration. [PDF]

J Psychopharmacol
Magar V, Robbins M, Fernández Lobo Blanco ÓML, Ali IL, Anderson B, Grob C, Henningfield JE, Kryskow P, Kuiper H, Loizaga-Velder A, Rush B, Volat M, Iron Rope S.   +12 more
europepmc   +1 more source