Results 41 to 50 of about 1,815,837 (309)

Social Capital, Innovation and Growth: Evidence from Europe [PDF]

This paper investigates the interplay between social capital, innovation and economic growth in the European Union. We identify innovation as an important mechanism that transforms social capital into economic growth. In an empirical investigation of 102
Akcomak, Semih, ter Weel, Bas
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Erasmus Innovative European Studies

, 2016
This paper introduces an ongoing Erasmus+ project granted in the KA2 “Cooperation for innovation and the exchange of good practices” call. The project was applied by the Gazi University (Turkey) and its duration is three years. It engages five universities and involves B.Sc., M.Sc. and Ph.D.
ALTIN, NECMİ, Lopez-Guede, Jose Manuel, Grana, Manuel, Ionescu, Valeriu, KURT, EROL   +4 more
openaire   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

An Automatic Dry Sieving Mechanism for a Lunar Brick Payload

Applied Sciences
This paper presents the design, implementation, and testing of an automated sieve system tailored for lunar regolith sorting to support ISRU applications, specifically targeting particles of 500 μm size.
Bram Verbruggen, Xiaochen Zhang, Aidan Cowley, Kathryn Hadler   +3 more
doaj   +1 more source

Towards a Simpler Characterization of Urban Sprawl across Urban Areas in Europe

Land, 2018
Urban sprawl is a concept commonly used to describe the physical expansion of urban areas. It is traditionally associated with lower residential density, poorer connectivity, and higher energy costs for heating and transport.
Jean-Philippe Aurambout, Ricardo Barranco, Carlo Lavalle   +2 more
doaj   +1 more source

Towards an Intellectual Property Rights Strategy for Innovation in Europe [PDF]

, 2009
On October 13, 2009 the Science and Technology Options Assessment Panel (STOA) together with Knowledge4Innovation/The Lisbon Forum, supported by Technopolis Consulting Group and TNO, organised a half-day workshop entitled ‘Towards an Intellectual ...
Radauer, Alfred, Rodriguez, Victor
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Innovation in The European Union Within The Framework of The Theory of Creative Destruction: An Overview After The Global Financial Crisis 2008

Ekonomi, Politika & Finans Araştırmaları Dergisi, 2020
Innovations are vital for economic development. Schumpeter, the famous economic theorist who drew attention to the innovation activities, was the first to reveal that capitalism has a structure that realizes development through innovations.
Altuğ Günar, Seyhun Doğan
doaj   +1 more source