Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno +19 more
wiley +1 more source
'Integration through Law' Revisited: The Making of the European Polity
, 2012 The contributors of this edited collection revisit one of the first academic projects to concepualise and study legal integration, the 'Integration through Law' project, started at the European University Institute, Florence, in 1978 and directed by ...
core +1 more source
Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello +10 more
wiley +1 more source
Milestones of European Integration: Which matters most for Export Openness? [PDF]
The European integration process has removed barriers to trade within Europe. We analyze which integration step has most profoundly influenced the trending behavior of export openness. We endogenously determine the single most decisive break in the trend,
Kruse, Robinson, Hiller, Sanne
core
The Promotion of Regional Economic Integration in the EU’s Neighbourhood: CEFTA 2006 and the Agadir Agreement. Bruges Regional Integration & Global Governance Paper 5/2009 [PDF]
, 2009 Regional integration scores alluringly high on the hit list of the most promising cures for the world’s major problems. Undoubtedly, the European Union has considerable experience in developing a sophisticated regional integration scheme – but does it ...
Willenberg, Anne
core +1 more source
Generalized Dystonia With Cervical Predominance in a Patient With a De Novo TCF20 Variant
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT TCF20 has been implicated in developmental delay and intellectual disability, with dystonia reported less frequently. We describe a woman in her early twenties with childhood‐onset learning difficulties, progressive dysarthria, tremor, and generalized dystonia with marked cervical predominance, associated with a de novo TCF20 frameshift ...
Melisa Kilic +7 more
wiley +1 more source
Between Free Trade and Social Goals: Regional Integration in the Iberian Peninsula and Mexico. Jean Monnet/Robert Schuman Paper Series, Vol. 3 No. 9, October 2003 [PDF]
, 2003 (From the introduction). This paper examines the integration process of Spain and Portugal in the European Union (EU) and of Mexico in the North American Free Trade Agreement (NAFTA).
Royo, Sebastián.
core
microRNA‐7‐5p and α‐Synuclein SAA Predict Parkinson's Disease Phenoconversion
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Corroborate blood neuron‐derived extracellular vesicle (NDEV) alpha‐synuclein (αSyn), the CSF αSyn seed amplification assay (αSyn‐SAA), and blood microRNA‐7‐5p (miR‐7‐5p) as markers for Parkinson's disease (PD) phenoconversion and determine if combining these markers would help select subjects who would be more likely to phenoconvert.
Shayan Zadegan +4 more
wiley +1 more source
"European Integration and Enlarging the European Union: A Theoretical Perspective" [PDF]
, 1995 [From the Introduction]. In the past ten years historic changes have taken place in Europe which have transformed not only the geography but also the political agenda of much of the continent.
Miles, Lee.
core
The Association of Amyloid‐β and Tau With Synaptic Dysfunction in Alzheimer's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To clarify the relative contributions of amyloid and tau to synaptic dysfunction in Alzheimer's disease (AD). Methods We included 109 cognitively unimpaired and impaired individuals from the Geneva Memory Center with available CSF synaptic biomarkers (neurogranin, SNAP‐25, GAP‐43). Participants were stratified according to amyloid (A)
Fausto Roveta +11 more
wiley +1 more source