Results 91 to 100 of about 6,956,885 (344)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

THE EVOLUTION OF LABOR LAW IN THE PROCESS OF EUROPEAN INTEGRATION OF NEIGHBORING COUNTRIES – THE EUROPEAN LABOR LAW, COMPARATIVE VIEW

Pravo, 2009
The author has tried to point out the importance of the analysis and parallel contemplation of experiences in the process of reforming of legal systems in the field of work and working relationships which will be expected to happen in our country in the ...
Igor Šoltes, Milan Počuča
doaj  

Nação e nacionalismo no século XXI Nation and nationalism in the 21st century

Estudos Avançados, 2008
Não obstante o processo de globalização, o Estado Nacional, para países dotados de satisfatória condição de autonomia, continua sendo o agente decisório.
Helio Jaguaribe
doaj   +1 more source

Charge Resistance in a Majorana RC circuit

, 2012
We investigate the dynamical charge response in a "Majorana Coulomb box" realized by two Majorana bound states hosted at the ends of a mesoscopic topological superconductor.
Golub, Anatoly, Grosfeld, Eytan
core   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Accountancy and Audit Within the National European Union Accession Program of the Republic of Croatia - Year 2004 [PDF]

On its session held on 15th January 2004, the Government of the Republic of Croatia has promulgated the Republic of Croatia’s National EU Accession Program - Year 2004, together with the Republic of Croatia’s Acquis Communautaire Legislation ...
Petar Proklin
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

From Inter-modal Transport Services to Integrated Common Objectives [PDF]

, 2011
The article starts from the paradigm of modernity and its connection to the technological basis with special regards to the technological determinations in the development of the transport modes.
Fleischer, Tamás
core  

Boosted Tidal Disruption by Massive Black Hole Binaries During Galaxy Mergers FROM The View of N-Body Simulation [PDF]

, 2016
Supermassive black hole binaries (SMBHBs) are productions of the hierarchical galaxy formation model. There are many close connections between central SMBH and its host galaxy because the former plays very important roles on the formation and evolution ...
Berczik, Peter, Li, Shuo, Liu, F. K., Spurzem, Rainer   +3 more
core   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source