Results 31 to 40 of about 229,492 (300)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

The implementation of the european landscape convention in the peri-urban environment

open access: yesARQUISUR Revista, 2019
The European Landscape Convention is an international treaty that is specifically and exclusively dedicated to European landscapes, although the issues it raises are of general interest.
Dra. Arq. María Isabel Alba Dorado
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Европейская ландшафтная конвенция в контексте зеленой экономики [PDF]

open access: yes, 2016
The European convention on landscapes (European Landscape Convention) has been adopted at the 718th meeting of Committee of Ministers of the Council of Europe (Strasbourg, on July 19, 2000), nominated to signing on October 20, 2000 at Conference of ...
Лебедева, Н. О.   +1 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

La convenzione europea del paesaggio: interpretazioni ed applicazioni

open access: yesRi-vista: Ricerche per la Progettazione del Paesaggio, 2015
The University of Florence, the Municipality of Florence and the Tuscan Region have promoted a conference on “The European Landscape Convention: interpretations and applications” that took place, last June 16, 2006, in the Salone dei Cinquecento of ...
Maria Felicia Della Valle
doaj   +1 more source

Glossary on renewable energy and landscape quality: the glossary [PDF]

open access: yes, 2018
The energy supply sector is considered a major polluter by the emission of greenhouse gases in the ...
Kruse, Alexandra, Mickovski, Slobodan B.
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

De los paisajes protegidos a la protección del paisaje: un reto pendiente

open access: yesRevista Vasca de Administración Pública, 2012
For a long time the landscape has been addressed by the law, both internationally and internally. However, also for a long time the landscape has been approached from a perspective excessively reductionist and sectorial. The European Landscape Convention,
Bartomeu Trias Prats
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

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