Results 241 to 250 of about 3,155,757 (335)

Akkermansia muciniphila‐derived hypoacylated rough‐type lipopolysaccharides alleviate diet‐induced obesity via activation of TLR4−IL‐23−IL‐22 immune axis

iMeta, EarlyView.
This study demonstrates that hypoacylated, rough‐type lipopolysaccharides (LPS) derived from Akkermansia muciniphila strain HW07 (ALPS) alleviates diet‐induced obesity. ALPS acts as a weak TLR4 agonist and significantly reduces weight gain, improves metabolic parameters, and restores gut barrier integrity in obese mice.
Li Sun, Yuting Zhang, Wang Dong, Jingzu Sun, Tao Wang, Fei Shao, Huanqin Dai, Junjie Han, Wenzhao Wang, Shuo Wang, Tong Zhao, Liangliang Wang, Chang Liu, Shuangjiang Liu, Hongwei Liu   +14 more
wiley   +1 more source

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

NR4A3 suppresses bladder cancer progression by modulating autophagy <i>via</i> the PI3K/AKT/mTOR pathway. [PDF]

Eur J Histochem
Fan L, Xu F, Liu S, Wu D, Wang S, Pan X, Zhou Y, Qu L, Zhou W.   +8 more
europepmc   +1 more source

Clinical and Serological Correlates of Serum C1Q and Anti‐C1Q Antibodies in South Africans With Systemic Lupus Erythematosus

Journal of Clinical Laboratory Analysis, EarlyView.
Raised anti‐C1q antibody titres in South Africans with SLE were associated with active LN, as evidenced by an active urine sediment. A positive anti‐C1q antibody and low serum C1q were associated with a positive Direct Coombs' test. ABSTRACT Objective To investigate prevalence and clinical correlates of serum C1q and anti‐C1q antibody titres in black ...
Mohammed Tikly, Lillemor Skattum, Mohamed Amin Makda   +2 more
wiley   +1 more source

Sex and sex hormonal regulation of the atrial inward rectifier potassium current (IK1): insights into potential pro-arrhythmic mechanisms. [PDF]

Cardiovasc Res
Giammarino L, Matas L, Alerni N, Horváth A, Vashanthakumar V, Nimani S, Barbieri M, Bains S, Lopez R, Louradour J, Ördög B, Hof T, Maguy A, Conte G, Auricchio A, Schotten U, Odening KE.   +16 more
europepmc   +1 more source

Illuminating Satellite Cells: Light Sheet Fluorescence Microscopy for 3D Imaging of Murine Skeletal Muscles Damaged by Ex Vivo Forced Eccentric Contraction

Microscopy Research and Technique, EarlyView.
This study presents the light sheet fluorescence microscopy (LSFM) as a tool for 3D‐imaging of whole skeletal muscle to reveal satellite cells (SCs), the muscle stem cells that activate following damage to repair injured tissue. After tissue clearing and whole‐mount staining process aimed to enable optical access and specific cell labeling (1), murine ...
Rachele Garella, Elisa Imbimbo, Francesco Palmieri, Alessia Tani, Martina Parigi, Flaminia Chellini, Alessandra La Contana, Monica Mattioli Belmonte, Aurora Longhin, Ludovico Silvestri, Chiara Sassoli, Roberta Squecco   +11 more
wiley   +1 more source

Diagnostic Accuracy of Lung Ultrasound in Rabbit Subclinical Lung Lesions. [PDF]

Vet Sci
Sargo R, Tomé I, Silva F, Ginja M.
europepmc   +1 more source

Harsh Winter Shocks and Distress Sales: Consumption and Asset Smoothing Among Livestock Farmers in Kyrgyzstan

Journal of International Development, EarlyView.
ABSTRACT The sale of livestock has long been considered a means of mitigation in case of drought, but there is no evidence of how this is achieved in the event of severe winters. This article focuses on the exceptionally harsh winter days that Kyrgyzstan experienced in 2012, as well as harsh winter days in other years, to analyse how livestock owners ...
Kadyrbek Sultakeev, Martin Petrick
wiley   +1 more source

Converting Health Level 7 Clinical Document Architecture (CDA) documents to Observational Medical Outcomes Partnership Common Data Model (OMOP CDM) by leveraging CDA Template definitions. [PDF]

JAMIA Open
Katsch F, Hussein R, Stamm T, Duftschmid G.   +3 more
europepmc   +1 more source

Association of In Vivo Kidney Stiffness Measured by Multifrequency MR Elastography and Long‐Term Renal Function in Transplant Recipients and Living Donors

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Kidney transplant (KTx) function assessment is important in treatment planning, while conventional MRI markers lack sensitivity for KTx function. Mechanical kidney properties may serve as MRI markers for renal allograft function. Hypothesis To determine if multifrequency MR elastography (MRE) is associated with KTx function.
Stephan Rodrigo Marticorena Garcia, Jonas Oppenheimer, Tom Meyer, Frank Friedersdorff, Ingolf Sack   +4 more
wiley   +1 more source