Results 81 to 90 of about 9,152,684 (304)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
European Union diplomacy: what role for training? EU Diplomacy Paper 03/2012, May 2012 [PDF]
, 2012 This paper examines how and why the European Union’s (EU) external relations training developed over time. In the European Commission diplomatic training began rather late in the 1990s but within a few years it gained momentum, in particular in the ...
Gstöhl, Sieglinde
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Post-modern Diplomacy: Can EU Foreign Policy Make a Difference in World Politics? EU Diplomacy Paper, 04/2011 [PDF]
, 2011 Although much discussed, there is in fact very little common EU foreign policy. The main reason for this is the reluctance, even the resistance of the member states to grant more authority to the Union in this field.
Mahncke, Dieter
core +1 more source
Phytosanitary Rules for the Movement of Olive (Olea europaea L.) Propagation Material into the European Union (EU). [PDF]
Plants (Basel), 2023 Montilon V +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Retracted: Can European Union (EU) Enlargement Boost Regional Economic Common Growth? Multi-Period Difference-in-Difference (DID) Method. [PDF]
J Environ Public Health, 2023 Environmental And Public Health JO.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Legal Personality of the European Union – Between the Maastricht Treaty and the Draft Treaty Establising a Constitution for Europe – Reality and Pperspectives [PDF]
Romanian Journal of European Affairs, 2006 The scope of the present article is to present an overview of the prevailing and accepted opinion on the legal personality of the European Union. The starting point of the presentation is the analysis of the structural differences between the EU and the ...
Octavian Gabriel Pascu +1 more
doaj
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source