Results 61 to 70 of about 1,070,207 (360)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A incorporação dos novos países à União Européia

Meridiano 47, 2017
O presente artigo busca delinear as conseqüências e impactos da expansão dos número de países integrantes do Bloco Europeu.
Miriam Gomes Saraiva
doaj  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Europa cresce

Meridiano 47, 2017
O presente artigo busca analisar o atual processo de expansão do bloco europeu, tendo como foco seus rumos e conseqüências, tanto para a União Europeia em si, quanto para cada país individualmente.
Estevão Chaves de Rezende Martins
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Foreign market selection process as tool for international expansion: Case study for ecuadorian chia seeds exports to the european union [PDF]

, 2020
Eduardo Terán-Yépez, Luna Santos‐Roldán, Beatriz Palacios‐Florencio, Juan M. Berbel‐Pineda   +3 more
openalex   +3 more sources

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

A Ampliação da União Europeia

Meridiano 47, 2017
O presente artigo busca analisar as vantagens comerciais a serem obtidas pelo Brasil como resultado do processo de ampliação da União Europeia.
João Augusto Baptista
doaj  

Energy and Environmental Challenges in the European Union and Green Bonds

Social Sciences
Could the European Union mitigate the negative effects of economic, pandemic and environmental crises using only one tool? The answer is positive, by implementing “green” fiscal expansion financed by “green” common debt, such as issuing green bonds.
Georgios Maris, Marios Psychalis
doaj   +1 more source

Physicians' migration in Europe: an overview of the current situation

BMC Health Services Research, 2007
Background The migration of medical professionals as a result of the expansion of the European Union is cause for concern. But there is a significant lack of information available about this phenomenon.
Amaya Carlos, García-Pérez Miguel A, Otero Ángel   +2 more
doaj   +1 more source