Results 51 to 60 of about 1,203,088 (377)

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Democracy and rule of law: the Hungarian goulash [PDF]

, 2013
The article discusses the Tavares Report on the new constitutional changes in Hungary, the implications of the new Constitution on Hungary's obligation under the Treaty, on European Union, especially its continuing commitment to the Union founding ...
Ressel, James
core  

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao, Katherine R Schon, Jana Vandrovcova, Özlem Yayıcı Köken, Sharika Raga, Kireshnee Naidu, Maryke Schoonen, Nimita Rani, Pedro Tomaselli, Dipti Baskar, Musambo Kapapa, Ipek Polat, Lindsay A Wilson, Kumarasamy Thangaraj, Uluç Yiş, Bevinahalli N Nandeesh, David Bearden, Michelle Kvalsund, Franclo Henning, Seena Vengalil, Atchayaram Nalini, Claudia F. R. Sobreira, Wilson Marques, Haluk Topoloğlu, Michael G Hanna, Sireesha Yareeda, Venugopalan Y Vishnu, Francois H van der Westhuizen, Izelle Smuts, Surita Meldau, Jo Wilmshurst, Büşranur Çavdarlı, Jeannine Heckmann, Patrick F Chinnery, Rita Horvath   +34 more
wiley   +1 more source

Environmental challenges and economic cooperation between Ukraine and the EU: prospects for sustainable development

Аналітично-порівняльне правознавство
The article is dedicated to analyzing the cooperation between Ukraine and the European Union, which began with the signing of the Partnership and Cooperation Agreement in 1994 and reached a new level after the signing of the Association Agreement in 2014.
V. Kononenko, О. Chernetska, Y. Fokin
doaj   +1 more source

Energy Communities: From European Law to Numerical Modeling [PDF]

arXiv, 2020
In 2019, the European Union introduced two new actors in the European energy system: Renewable and Citizen Energy Communities (RECs and CECs). Modelling these two new actors and their effects on the energy system is crucial when implementing the European Legislation, incorporating energy communities (ECs) into the electric grid, planning ECs, and ...
arxiv  

ADAPT NXT: Fixed Cycles or Every‐Other‐Week IV Efgartigimod in Generalized Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This phase 3b, open‐label, randomized ADAPT NXT study investigated the efficacy, safety, and tolerability of efgartigimod administered in either a fixed cycles dosing regimen (3 cycles of 4 once‐weekly infusions, with 4 weeks between cycles) or a cycle followed by every‐other‐week (Q2W) dosing.
Ali A. Habib, Kristl G. Claeys, Vera Bril, Yessar Hussain, Kelly Gwathmey, Gregory Sahagian, Elena Cortés‐Vicente, Edward Brauer, Deborah Gelinas, Anne Sumbul, Rosa H. Jimenez, Daniela Hristova, Delphine Masschaele, Renato Mantegazza, Andreas Meisel, Shahram Attarian, On behalf of the ADAPT NXT Study Group   +16 more
wiley   +1 more source

Reflections On Crossing The Boundaries Between Public And Private Law In Implementing The “European Green Deal."

Administrative and Environmental Law Review, 2021
Climate change brings new challenges to the world. With its high environmental standards, the European Union is one of the most active players in global climate action.
Tomasz Bojar-Fijalkowski
doaj   +1 more source

Elasticity of Diametrically Compressed Microfabricated Woodpile Lattices

Advanced Engineering Materials, EarlyView.
Modulus–porosity relationship is derived for woodpile lattices with struts under diametrical compression. The formula presented here that Young's modulus is proportional to the square of the volume fraction E˜ρ2$E \sim \left(\rho\right)^{2}$ is shown to be consistent with computations and laboratory experiments on 3D‐printed samples.
Faezeh Shalchy, Atul Bhaskar
wiley   +1 more source

On the Rigidity and Mechanical Behavior of Triply Periodic Minimal Surfaces‐Based Lattices: Insights from Extensive Experiments and Simulations

Advanced Engineering Materials, EarlyView.
This study examines the mechanical properties of triply periodic minimal surfaces (TPMS)‐based lattices, analyzing 36 architectures in elastic and plastic regimes. It evaluates the applicability of beam‐based scaling laws to TPMS lattices. Rigidity arises from the alignment of members with the load direction and solid regions preventing rotation.
Lucía Doyle, Humberto Terrones, Carlos González   +2 more
wiley   +1 more source