This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti +27 more
wiley +1 more source
Employee Rights Resulting from the European Union Directives and Their Enforceability in the Private Sector [PDF]
The paper summarizes the case law of the Court of Justice of the European Union, which has led to exceptions to the principle prohibiting the direct horizontal effect of directives in the field of employment law.
Tereza Erényi
doaj +1 more source
Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec +5 more
wiley +1 more source
Prohibition of Discrimination on Grounds of Sexual Orientation: Selected Case Law of the European Court of Human Rights [PDF]
The author deals in the paper with non-discrimination legislation in the European Union law and selected case law of the Court of Justice of the European Union and the European Court of Human Rights, with respect to the prohibition of sexual orientation ...
Katarína Procházková
doaj
Rapid Fabrication of Self‐Propelled and Steerable Magnetic Microcatheters for Precision Medicine
A rapid Joule heating fabrication method for the production of self‐propelling, adaptive microcatheters, with tunable stiffness and integrated microfluidic channels is presented. Demonstrated through three microrobotic designs, including a steerable guiding catheter, an untethered wave‐crawling TubeBot, and a distal‐end propelled microcatheter, it was ...
Zhi Chen +5 more
wiley +1 more source
From the European Green Deal’s Goal of Climate Neutrality to the Clean Industrial Deal: An Approach from the Perspective of the Protection of Human Rights [PDF]
The European Green Deal (EGD), which was adopted on 11 December 2019, placed people in the centre of its objective of achieving a climate-neutral economy and a sustainable society by 2050.
Gabriela A. Oanta
doaj
The Use of the Preliminary Ruling Procedure by Czech Courts: Historical Retrospective and Beyond
The article analyses the use of the preliminary ruling procedure by the Czech courts in the 15 years of the Czech membership in the European Union.
Stehlík Václav, Sehnálek David
doaj +1 more source
Why is a European Law on Disability Discrimination important [PDF]
EU law offers great potential for advancing the rights and interests of disabled people living within the European Union, but this potential is yet to be fully realised.
Whittle, R.
core
Strain Engineering of Magnetoresistance and Magnetic Anisotropy in CrSBr
Biaxial compressive strain significantly enhances magnetoresistance and critical saturation fields in thin flakes of the 2D magnet CrSBr, along all three crystallographic axes. First‐principles calculations link these effects to strain‐induced increases in exchange interactions and magnetic anisotropy.
Eudomar Henríquez‐Guerra +19 more
wiley +1 more source
Highly water‐soluble dicationic bis(indolium) dyes have been prepared, showing excellent two‐photon absorption and light emission. Their fluorescence behavior discloses an unusual increasing blue shift with increasing solvent polarity, which, in parallel, is beneficial for enhanced detection in biological media.
Carlos Benitez‐Martin +5 more
wiley +1 more source

