Results 61 to 70 of about 9,735,164 (257)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
European and World Values Surveys Four-Wave Integrated Data File, 1981-2004
, 2006 This survey is a not up-to-date version and available only for replication purposes (see ´Further Remarks´). Moral, religious, societal, political, work, and family values of citizens in EVS/WVS participating countries.
European Values Study Group +1 more
core +2 more sources
Quo vadis, European Union? [PDF]
CES Working Papers, 2019 The general objective pursued through this research is to map out the main perspectives on the future of the European Union in the new legislature elected following the May 2019 elections, with regard to the main attitudes and preferences shaping the ...
Vladimir-Adrian COSTEA
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Journal of Modern ScienceObjectives The aim of the article is to discuss the innovative work of Professor Antonio Magliulo, History of European Economic Thought, to indicate thematic areas for further discussion and polemics areas for continuation of his research.
Adam Czesław Halemba
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Life Wins in the West. Agnieszka Holland’s East-European Interpretation of The Secret Garden [PDF]
Acta Iassyensia ComparationisThe author of this essay interprets Agnieszka Holland’s cinematographic adaptation of Frances Hodgson Burnett’s The Secret Garden as a work of an East-European creator musing on the essence of Western civilisation and comments on it in the context of the
ŁUKASZYK EWA
doaj +1 more source