Results 81 to 90 of about 3,468 (199)

5‐Methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden, Michael Kelleher, Fiona Dunbar, Anna O. Ermakova, Luke Mitcheson, Claire Roberts, James J. Rucker, Gemma Scott, Ivan Saeger, Francesca Small, Mathieu Seynaeve   +10 more
wiley   +1 more source

Promoting smoking cessation and preventing relapse to tobacco use following a smokefree mental health in‐patient stay: A multi‐centre randomised controlled feasibility study

Addiction, EarlyView.
Abstract Aims This study assessed the feasibility and acceptability of a new theory‐ and evidence‐based intervention designed to prevent return to pre‐admission smoking behaviours after discharge from a smokefree mental health in‐patient setting in the United Kingdom (UK).
Petal Petersen Williams, Lisa Huddlestone, Emily Shoesmith, Jennifer Sweetman, Heidi Stevens, Alex Mitchell, Fraser Wiggins, Lesley Sinclair, Victoria Exley, Catherine Hewitt, Judith Watson, Qi Wu, Jodi Pervin, Moira Leahy, Claire Paul, Lion Shahab, Michelle Horspool, Tim Coleman, Simon Hough, Elena Ratschen, the SCEPTRE Collaboration team, Lesley Colley, Samantha Brady, John Britton, Simon Gilbody, Steve Parrott, Peter Coventry, Gregor Russell, Paul Galdas   +28 more
wiley   +1 more source

Factors Associated With Health-Related Quality of Life among Hypertensive Patients in Kathmandu, Nepal

Frontiers in Cardiovascular Medicine, 2017
IntroductionNepal has a high prevalence of hypertension. While improving the overall health-related quality of life (HRQOL) is a central tenet to public health plans in developed nations, this focus has yet to be articulated in Nepal.
Saruna Ghimire, Praful Pradhananga, Binaya Kumar Baral, Naveen Shrestha, Naveen Shrestha   +4 more
doaj   +1 more source

Intensive care decision‐making, survival and dying well: a mixed methods study with people who have been intensive care patients

Anaesthesia, EarlyView.
Summary Introduction Admission to the ICU involves experiential burdens and a risk of a negative dying experience if patients do not survive their critical illness. Many patients who are critically unwell, or their surrogate decision‐makers, must decide about accepting ICU treatment without knowing what it is like.
Thomas Donaldson, Kirsty Keywood, Lucy Frith, Søren Holm   +3 more
wiley   +1 more source

Cost‐effectiveness analysis of total intravenous vs. inhalation anaesthesia among adults aged ≥ 50 y undergoing major non‐cardiac surgery

Anaesthesia, EarlyView.
Summary Introduction Total intravenous and inhalational anaesthesia are used widely to maintain general anaesthesia for major non‐cardiac surgery, yet their comparative cost‐effectiveness remains uncertain. The VITAL trial evaluated clinical outcomes, showing no difference in days alive and at home at 30 days.
Samuel Frempong, Rebecca Kandiyali, James Mason, Louise Hiller, Janet Dunn, Katie Booth, Ramani Moonesinghe, Rupert Pearse, Ben Shelley, Shaman Jhanji, Joyce Yeung, on behalf of the VITAL Trial Team   +11 more
wiley   +1 more source

Virtual Care of Acute Diverticulitis: A Phase I/II Randomised Clinical Feasibility Trial

ANZ Journal of Surgery, EarlyView.
Virtual care for acute uncomplicated diverticulitis appears feasible, safe and acceptable, with potential advantages over inpatient care, including superior patient‐reported experience. ABSTRACT Background Acute uncomplicated diverticulitis is commonly managed in hospital in Australia.
Phillip F. Yang, Philip Hay, Owen R. Hutchings, Rebecca A. Davis, Miranda Shaw, Shanmugam S. Somasundaram, Michael J. Solomon, Peter J. Lee, Kate E. McBride, Daniel Steffens, Kheng‐Seong Ng   +10 more
wiley   +1 more source

Factors Affecting Surgical Outcomes Following Rotationplasty in Paediatric Sarcoma: A Literature Review

ANZ Journal of Surgery, EarlyView.
Rotationplasty is a durable limb‐salvage option for paediatric lower‐limb sarcoma. Across 58 studies and 1,217 patients, long‐term functional, psychosocial, and quality‐of‐life outcomes were favourable, often surpassing amputation and endoprosthetic reconstruction.
Rachel H. Ko, Stewart Morrison, Daniel J. Wilks   +2 more
wiley   +1 more source

Estimation of EuroQol 5-Dimensions health status utility values in hereditary angioedema

Patient Preference and Adherence, 2016
Emel Aygören-Pürsün,1 Anette Bygum,2 Kathleen Beusterien,3 Emily Hautamaki,4 Zlatko Sisic,5 Henrik B Boysen,6 Teresa Caballero7 1Angioedema Centre, Department for Children and Adolescents, University Hospital Frankfurt, Goethe University,
Aygören-Pürsün E, Bygum A, Beusterien K, Hautamaki E, Sisic Z, Boysen HB, Caballero T   +6 more
doaj  

Comparative Real‐World Effectiveness of Anti‐TNF, Ustekinumab and Vedolizumab in Crohn's Disease Over 24 Months: A Pooled Analysis From the Prospective UMBRELLA‐IBD Registry in Germany

Alimentary Pharmacology &Therapeutics, EarlyView.
A pooled analysis from the prospective UMBRELLA‐IBD registry in Germany (n = 1567) showed comparative real‐world effectiveness in treatment persistence and clinical remission of anti‐TNF, Ustekinumab and Vedolizumab in Crohn's disease patients over 24 months.
Arne Bokemeyer, Florian Tran, Sandra Plachta‐Danielzik, Elena Gilman, Thomas Wenske, Matthew Gaskins, Stefan Schreiber, Bernd Bokemeyer   +7 more
wiley   +1 more source

Utilización del cuestionario European Quality of Life-5 Dimensions (EQ-5D) para valorar la variación de la calidad de vida relacionada con la salud debida a la gripe Use of European Quality of Life-5 Dimensions (EQ-5D) questionnary to value the health related quality of life variation because of influenza

Gaceta Sanitaria, 2009
Objetivo: Describir el estado de salud autopercibido y la calidad de vida relacionada con la salud (CVRS) de individuos sanos en edad laboral, medir el cambio experimentado con el padecimiento de la gripe y valorarlo en términos monetarios.
Roberto Pradas Velasco, Fernando Antoñanzas Villar, María Puy Martínez-Zárate   +2 more
doaj