Results 41 to 50 of about 47,009 (288)

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

A randomized controlled trial of a multimodality digital health intervention to aid the delivery of the modified ketogenic diet therapy for epilepsy: The Keto eCoach trial protocol

Epilepsia Open, EarlyView.
Abstract Objective Dietary therapy is an effective treatment for drug‐resistant epilepsy; however, low adherence presents a significant barrier to use in the clinical setting. This study aims to evaluate a multimodality digital health intervention to overcome this barrier and improve outcomes in adults undertaking the modified ketogenic diet for ...
Neha Kaul, Lucy Vivash, Susanna Chen, Lillian King, Hannah Johns, Leonid Churilov, Zhibin Chen, John‐Paul Nicolo, Danielle Heaven, Ella Meredith, Ryan Ervine, Lisa Todd, Bernadette Zappa, Zanfina Ademi, Gopisankar Mohanannair Geethadevi, Michael Erlichster, Efstratios Skafidas, Terence J. O'Brien, Patrick Kwan   +18 more
wiley   +1 more source

Case‐Mix Adjustment of Multidimensional Patient‐Reported Outcomes to Assess Hospital Performance

Health Economics, EarlyView.
ABSTRACT Multidimensional patient‐reported outcome measures (PROMs) are increasingly used to compare the performance of health care providers. Meaningful comparisons require the data to be adjusted for differences in case‐mix. The common approach in the literature is to aggregate PROM data into univariate summary scores prior to case‐mix adjustment. In
Nils Gutacker, Yuanyuan Gu
wiley   +1 more source

MODELLING THE EQ VAS USING THE QUANTILE REGRESSION IN ORDER TO EXPLAIN LIFESTYLE DETERMINANTS EFFECT ON QUALITY OF LIFE

, 2006
Objective. The aim of this study is to propose a new approach for modelling the EQ-5D VAS, in order to explain the lifestyle determinants effect using the quantile regression analysis. Methods and Results.
BROCCOLI, SERENA, Mattivi A., CAVRINI, GIULIA, Pacelli B.   +3 more
core   +1 more source

RELATIONSHIP BETWEEN PHYSICAL ACTIVITY AND HEALTH-RELATED QUALITY OF LIFE IN ELDERLY PEOPLE: A CROSS SECTION STUDY

Sanamed, 2017
Objectives: This study aimed to investigate the relationship between physical activitylevel and health related quality of life in elderly people. Design: Between January and April 2017, a cross-sectional study of 114 elderly people (73 males and 41 ...
Walid Kamal M. Abdelbasset, Gopal Nambi S   +1 more
doaj   +1 more source

The Optimal Lung Cancer Ct Screening Strategy: A Cost‐Effectiveness Study Incorporating Nelson Evidence, Evolving Cost of Treatment and Smoking Cessation Interventions

International Journal of Cancer, EarlyView.
ABSTRACT Lung cancer screening implementation is taking shape worldwide. Programme design requires specifying eligibility criteria, screening interval, and the optimal age range. We estimate benefits and harms of competing strategies, integrating NELSON results, smoking cessation interventions, contemporary treatment costs, and the management of ...
Koen de Nijs, Kevin ten Haaf, Dana Moldovanu, Juul Hubert, Isabelle van den Bosch, Carlijn van der Aalst, Harry J. de Koning   +6 more
wiley   +1 more source

Maternal tobacco exposure and health-related quality of life during pregnancy: a national-based study of pregnant women in China

Health and Quality of Life Outcomes, 2021
Background With the increase of the number of smokers, tobacco exposure among pregnant women is becoming more and more common. Pregnant women exposed to first-hand smoke and second-hand smoke are susceptible to physiological and psychological health ...
Weiwei Sun, Xinyu Huang, Huailiang Wu, Casper J. P. Zhang, Zongzhi Yin, Qianqian Fan, Huiyun Wang, Pallavi Jayavanth, Babatunde Akinwunmi, Yanxin Wu, Zilian Wang, Wai-kit Ming   +11 more
doaj   +1 more source

Ethnic differences in health related quality of life for patients with type 2 diabetes [PDF]

, 2014
Background: The objective of this study was to investigate the association between ethnicity and health related quality of life (HRQoL) in patients with type 2 diabetes. Methods: The EuroQol EQ-5D measure was administered to 1,978 patients with type 2
Stavros Petrou, Gumber, Anil, Szczepura, Ala, Anil Gumber, Srikanth Bellary, Petrou, Stavros, Raymond, Neil T, Jhita, Tracey, Ala Szczepura, Neil T Raymond, Tracey Jhita, Raymond, Neil T., Bellary, Srikanth   +12 more
core   +1 more source

EuroQoL in assessment of the effect of pulmonary rehabilitation COPD patients [PDF]

Respiratory Medicine, 2008
The effect of pulmonary rehabilitation on EuroQol in COPD patients has not been investigated previously.Two hundred and twenty nine consecutive COPD patients who had completed a 7-week pulmonary rehabilitation programme were assessed with EuroQol five-dimension questionnaire (EQ-5D), endurance shuttle walk test (ESWT), and the St George's Respiratory ...
Ringbaek, Thomas, Brøndum, Eva, Martinez, Gerd, Lange, Peter   +3 more
openaire   +3 more sources

Comparison of treatment pathways for isolated mesh associated pain syndrome (I‐MAPS) secondary to pelvic mesh devices for stress urinary incontinence (SUI)

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The aim of this retrospective observational cohort study was to compare the outcome of surgical, combined and non‐surgical pathways of isolated mesh associated pain syndrome (I‐MAPS) following insertion of a single continence tape. Methods Women with a single continence tape who experienced I‐MAPS accessing the service between 2018 ...
Hawra Badri, Emily Whyley, Bharati Vyawahare, Zainab Al‐Jawahiri, Karen Ward, Richard Edmondson, Fiona Reid   +6 more
wiley   +1 more source