Results 51 to 60 of about 47,291 (279)

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Relationship between the EQ-5D index and measures of clinical outcomes in selected studies of cardiovascular interventions [PDF]

, 2009
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Buxton, Martin J, Schofield, Peter M, Peter M Schofield, Kimberley A Goldsmith, Sharples, LD, Goldsmith, Kimberley A, Dyer, MT, Sharples, Linda D, Schofield, PM, Goldsmith, Kimberley A; id_orcid, Matthew T Dyer, Linda D Sharples, Goldsmith, KA, Dyer, Matthew T, Martin J Buxton, Buxton, MJ   +15 more
core   +6 more sources

A randomized controlled trial of a multimodality digital health intervention to aid the delivery of the modified ketogenic diet therapy for epilepsy: The Keto eCoach trial protocol

Epilepsia Open, EarlyView.
Abstract Objective Dietary therapy is an effective treatment for drug‐resistant epilepsy; however, low adherence presents a significant barrier to use in the clinical setting. This study aims to evaluate a multimodality digital health intervention to overcome this barrier and improve outcomes in adults undertaking the modified ketogenic diet for ...
Neha Kaul, Lucy Vivash, Susanna Chen, Lillian King, Hannah Johns, Leonid Churilov, Zhibin Chen, John‐Paul Nicolo, Danielle Heaven, Ella Meredith, Ryan Ervine, Lisa Todd, Bernadette Zappa, Zanfina Ademi, Gopisankar Mohanannair Geethadevi, Michael Erlichster, Efstratios Skafidas, Terence J. O'Brien, Patrick Kwan   +18 more
wiley   +1 more source

ASSESSMENT OF THE RELATIONSHIP BETWEEN OBESITY AND QUALITY OF LIFE IN ADOLESCENTS: A POPULATION BASED STUDY

, 2007
Background: Obesity is one of the most chronic disorders in childhood and its prevalence continues to increase rapidly. Although there is a growing awareness of the long-term health implications of obesity in children and adolescents, the more ...
Barbara Pacelli, BROCCOLI, SERENA, CAVRINI, GIULIA   +2 more
core   +1 more source

DOES CARDIAC REHABILITATON IMPROVE HEALTH RELATED QUALITY OF LIFE?

, 2006
Backgrounds: The integration of EQ-5D questionnaire in the standard core set of utilized outcome measures may be useful aiming at a whole evaluation of cardiac rehabilitation improvements.
A. Mattivi, G. Balestroni, A. M. Zotti, BROCCOLI, SERENA, B. Pacelli, CAVRINI, GIULIA   +5 more
core   +1 more source

Content validity of the EQ-HWB and EQ-HWB-S in a sample of Italian patients, informal caregivers and members of the general public

Journal of Patient-Reported Outcomes
Background The EuroQol Group recently developed two new instruments, the EQ Health and Wellbeing (EQ-HWB) and the EQ Health and Wellbeing short version (EQ-HWB-S).
Sara Masutti, Camilla Falivena, Fredrick Dermawan Purba, Claudio Jommi, Clara Mukuria, Aureliano Paolo Finch   +5 more
doaj   +1 more source

Mapping clinical outcomes to generic preference-based outcome measures: development and comparison of methods

Health Technology Assessment, 2020
Background: Cost-effectiveness analysis using quality-adjusted life-years as the measure of health benefit is commonly used to aid decision-makers. Clinical studies often do not include preference-based measures that allow the calculation of quality ...
Mónica Hernández Alava, Allan Wailoo, Stephen Pudney, Laura Gray, Andrea Manca   +4 more
doaj   +1 more source

Outcomes of patients with post‐stroke epilepsy: A scoping review on quality of life, readmissions, costs, seizure recurrence, and medication adherence

Epilepsia Open, EarlyView.
Abstract Objective Post‐stroke epilepsy (PSE) affects ≈10% of patients with stroke and is associated with adverse health and economic outcomes. We aimed to review published literature on health and economic outcomes for patients with PSE, with a specific focus on quality of life, hospital readmissions, healthcare costs, seizure recurrence, and ...
Nega Dagnew Baye, Emma Foster, Muideen T. Olaiya, Nigel C. Jones, Monique F. Kilkenny, Lachlan L. Dalli   +5 more
wiley   +1 more source

Patient Journey, Disease Burden, Treatment Patterns, and the Impact of Delayed Diagnosis Among Patients With Sjögren's Disease: A Real-World US Survey. [PDF]

ACR Open Rheumatol
Objective The aim of this study was to investigate disease burden, treatment patterns, and impact of delayed diagnosis on patient outcomes in Sjögren's disease (SjD) in a real‐world setting in the United States. Methods Data were drawn from the Adelphi Primary Sjögren's Syndrome Disease Specific Programme, a US‐based cross‐sectional collaborative ...
Lalla A, Egana A, Milligan J, Massey N, Haughton J.   +4 more
europepmc   +2 more sources

Effectiveness of a Primary‐Care‐Centered Integrated Care Intervention for Stratified Cardiovascular Risk Control in China: Study Protocol for a Pragmatic Cluster Randomized Controlled Trial

Health Care Science, EarlyView.
This study developed a multifaceted intervention to strengthen primary care for cardiovascular risk management by leveraging both primary care and county hospitals in rural China. The purpose of this multicentre, cluster‐randomized controlled trial is to evaluate the effectiveness of intervention on the prevention of cardiovascular risks among patients
Weijia Lu, Xinxin Xia, Ziming Wang, Yaoyun Zhang, Yiting Lin, Wuxiang Xie, Jin Xu   +6 more
wiley   +1 more source