Results 111 to 120 of about 3,376,137 (308)

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

The future of euthanasia politics in the Australian state parliaments [PDF]

, 2014
There has been significant activity on voluntary euthanasia, with bills seeking to reform the law on the practice introduced in all of the Australian state parliaments except Queensland.
Alison Plumb
core  

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Euthanasia in the Netherlands

, 1990
Brahams reviews the situation in the Netherlands where doctors who practice active euthanasia within narrow guidelines are unlikely to be prosecuted or disciplined, even though the act remains a criminal offense under Dutch law.
Brahams, Diana
core  

Christian views of euthanasia: a comparison of Russian and western perspectives [PDF]

, 2003
The following research aims at unfolding an authentic Christian attitude to euthanasia by means of a comparative analysis of Christian bioethical thinking and practice in Russia and in the West.
Lastochkina, Maria
core  

One Physician's Perspective: Euthanasia and Physician-Assisted Suicide

, 2004
This paper looks at the ambiguities which PAS (physician assisted suicide) and voluntary active euthanasia (VAE ) present to the patient, his or her loved ones and the health-care team.
Pugno, Perry A.
core   +1 more source

Aruna Shanbaug. A Case Study in Compassion, Dignity, and the Ethics of Euthanasia

Journal of Legal Studies
The case of Aruna Shanbaug is a landmark case in Indian jurisprudence that significantly influenced the debate surrounding the right to die with dignity.
Navin Kumar
doaj   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

EUTHANASIA AND THE COUNTRIES WHICH POSITIVELY REGULATED ACTIVE EUTHANASIA

Journal of Law and Sustainable Development
Objectives: The main objective of this article is to provide a comprehensive understanding of Euthanasia, also known as mercy-killing, and its various forms. It also aims to discuss the moral and legal implications of Euthanasia, which differ across countries, and examine the statutory frameworks of jurisdictions where Active Euthanasia has been ...
Dubey, Mayank, Rathi, Amita, Singh, Hitendra   +2 more
openaire   +1 more source

Hyper‐Intense Tumor Peripheral Accumulation of Antibody‐Conjugated Iron Oxide Nanoparticles can Enable Breast Cancer Detection by Magnetic Particle Imaging

Advanced Science, EarlyView.
Tumor‐associated inflammation retains antibody‐targeted or non‐specific antibody conjugated nanoparticles within the tumor microenvironment. Magnetic Particle Imaging (MPI) enables non‐invasive detection and differentiation of tumors from other organs, owing to higher nanoparticle retention by inflammatory cells in the tumor periphery.
Preethi Korangath, Hayden Carlton, Theresa Wong, Sean Healy, Toby Sanders, Mason Song, Patrick W. Goodwill, Cordula Grüttner, Kathleen Gabrielson, Robert Ivkov   +9 more
wiley   +1 more source